Revealing the Hidden Causes of Autoimmune Diseases

Question: How to Find the Root Cause of Autoimmunity?

Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism.

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Can NAC hurt your gut health?
Why Would Vitamin C Cause Joint Pain, Muscle Pain, and Brain Fog?

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This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

*GLA to lower hydroxyhaemopyrrolin-2-one?
*When would I use the StrateGene and Genova Methylation Panel for nutritional testing?
*Energy metabolism as a root cause of gut issues?
*Nutrition for skin healing?
*Nutrition for hypnic jerks?
*Suggestions for snoring or sleep apnea?
*Nutrition to protect against restaurant meals?
*What is the cause of crusty eyes in the morning?
*What causes brain fog?
*How much oxalate should one eat each day?
*Should I be concerned about low alkaline phosphatase?
*What nutrients give tall children to short parents?
*Energy metabolism impairment mimicking Wilson's disease.
*Can taking digestive enzymes reduce our own production?
*Rapid-fire response to non-winners from the question contest.

[mscoldham]

The answer to this would change my life!!

[mercychesed]

Yes, this is my experience. Told I had the autoimmune condition Interstitial cystitis. Only recovered when vitamin A began being activated to retinoic acid.

[rdance]

When I first sought the care of my rheumatologist, I made the comment that when I'm sick, I actually feel better. I actually found an article that echo'd my experiences. She stated that this is common with autoimmunity. I've been on biologics for 20 years now. They definetly help but they are not perfect. I often theorize ways to introduce pathogens that help act as a "sacrifcial immune buffer". Maybe a pill formed probiotic that contains weakened pathogens that can break through the leaky gutt in the tight junctions, that is common in many people who suffer.

[larsnystrom]

Those growing up where theres enough sun until they are mid teenagers have much less of autoimmune diseases.
In Finland they tried giving babies a little more of vitamin D. That reduced the frequency of MS substantially.
We have noticed the differences in allergies and asthma depending on sun exposure.
Some MD:s are sucessfully treating autoimmune diseases with very high doses of vitamin D.
What this indicates is that the immune system needs vitamin D especially when it's developing.
It seen like it cannot fully be recovered later, when grown up, if an autoimmun diseas already has developed.
Unfortunately, there's some extraordinary resistance against doing research on vitamin D with doses giving blood levels of 25(OH)D of at least 50 ng/ml, where the immune system effects are fully gained.

[codig.]

What about Dr. Naviaux cell danger response? Also the idea that it’s not random, that the body has turned on a state of protecting the cell and in that process we have all these uncomfortable symptoms but the body doesn’t care about how we feel because it’s goal is to keep us alive. The problem he says is that the body gets stuck in a state of cell danger response (CDR) and it can be hard to switch it off. He figured out the purinergic drug suramin could help with this. The pilot study they did on autistic children at UCSD is exciting! He thinks this theory could also apply to all autoimmune conditions and new viruses. We don’t want to wait for a drug if we can turn of the cell danger response with the right tools. Your thoughts on CDR and how we can do this?

[StarHarvestOfficial]

I got alcohol and caffeine intolerance after I became toxic in B6. Is there anything that's helped your clients with that?

[acoranquesadadiaz]

Could someone please explain how to fix energy metabolism?

[rdance]

As a person who uses biologics at a 12 week frequency, I have swung from high energy/low inflammation to the complete opposite. The correlation is so tight, it's hard to determine which comes first. In my amature studies of metabolic pathways, I often see that certain enzymes are inhibited by immune markers like IL6, TNF etc...This correlation is the bane of my existance. It's like the "chicke and the egg". Sometimes I feel that my low energy is the product of my inflammation and other this I'm of the opinion that my inflammation is the cause of poor nutrient absorption.

[nadernayo]

pretty complicated chris .. but i got the idea finally.. thanks genius.

[douggrant]

How do u determine a respiring chain disorder

[self-purpose]

riboflavin, should i use free instead of riboflavin 5'-phosphate if i put it on my skin with DMSO since it needs to be converted in intestines? thank you

[allisonjones]

EPI - Lucy Mailing metnioned recently she sees a lot of undiagnosed celiac being a cause of this. Also when I researched it, SIBO is linked to EPI.

[inittiela]

Chris can you say your opinion on ttfd suplement and generally about high dosing b1 for some time taking in account that most people have high carb diets for whole life so it would bring their b1 to normal?

[musaire]

autism is also believed to be an auto-immune issue. Antibodies attacking the brain. In child, I wonder how complicated it would be to erase that immune pattern that their parents caused them (usually their brains are attacked in the womb already) - not easy in kids, immune in children acts differnetly compared to an adult - fasting is dangerous in children for example - not enough food for immune cells, immunoglubulins in digestive tract may get lowered etc.

[timwhite]

Entropy does not increase at a constant immutable rate. You do control that rate. Efficiency of a mechanism is related to that. There is a limit to that efficiency dictated by 2nd law\entropy.
Not really a constructive approach to pathologies, more a distraction. Metabolism specifics you use well.

[nootri]

I'm not getting something here. These people are not in a bedridden, debilitated or vegetative state, are they? They do create some energy. Why doesn't getting a good amount of rest helping them? How does a moment by moment sort of restricted capacity of the respiratory chain in the now become a bottle-neck over the long term also? If ATP is metabolic currency, why is there never enough spare change to redirect, so that at some point those issues are addressed? It's not like over-training makes one autoimmune, isn't it? Anyone?

[amyfaith]

Fix the gut infection first has been my reality, at least once. What's is your perspective?

[larsnystrom]

I know a few with autoimmune diseases, such as artrit, asthma, and MS.
None of them show any sign of energy deficency. There's probably nothing wrong with their ATP production.
Is that really a main cause of autoimmune diseases?
He didn't mentioned creatine. That should be important for using the ATP efficiently.

[jenniferflower]

Your body and I would add, your mind is in a state of cognitive dissonance.

[musaire]

for most auto-immune conditions, just do green smoothies and some seeds and nuts for omega-3 for few months. Then add other foods back in.
Surely, energy governs all, but all those phytos and minerals and vitamins from there, wihtout the excess crap, is what directs the energy metabolism the way we need