The Sleep-Alzheimer's Connection

Join us Dec. 16 to hear from David Holtzman, M.D., about his groundbreaking work on the connection between sleep and Alzheimer's disease, and sleep’s possible role in managing the brain’s Abeta and tau burdens.
 
“We found that, in the brains of animals and humans, Abeta is regulated by neuronal activity,” Holtzman says. “The levels of Abeta fluctuated during the day and night. During wakefulness, the levels of protein were higher than when sleeping, and if an animal was sleep-deprived, it caused a much earlier onset of Abeta deposition in the brain. This suggests that if you optimize non-REM (deep) sleep, it might delay the onset of Alzheimer’s disease. But once you get the pathology, it further disrupts your sleep.”
 

[aaron___]

So none of this talk is conclusive. So I'll give you some advice; prioritize sleep over staying up late (read a book in the evenings), exercise in a way the elevates your heart rate, eat a Mediterranean diet, and deal with your stress in a healthy manner. Bonus, this will help prevent more than just Alzheimers!

[PaulHigginbothamSr]

Exactly the things downstream from the scene of the crime. Tau proteins happen when this disorder manifests. Quick onset is probably a gut bacteria gone rogue in the brain.

[GospodinJean]

And I'm watching this video instead of sleeping