Treating the DISEASES of OLD AGE should begin at 45

An interesting study on aging out of Duke University using data that has been collected on people as they age since the 1970’s.


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This a review of a piece written by Sarah Avery of the Duke University School of Nursing. She says, people grow old at different rates, regardless of what the calendar says. And for those whose bodies age more quickly, the cumulative effects show up as early as midlife, when signs of dementia and physical frailty begin to emerge. The findings were published in the journal Nature Aging and suggest that identifying and treating the diseases of old age should begin around the time people celebrate their 45th birthday. This is before the problems escalate, degrade people’s quality of life and impose huge costs on people and society. The lead author, Maxwell Elliott, who is a Ph.D. student in Duke's Department of Psychology & Neuroscience said "Aging isn't something that happens suddenly when people reach their 60s, it's a lifelong process. We have a way of measuring how quickly people are aging, and our findings highlight the importance of addressing biological aging in midlife while prevention is possible and before heavy organ damage has accumulated." The researchers including senior author Terrie Moffitt, a Professor in Psychology & Neuroscience, created a unique database using a study that was started in New Zealand in the 1970’s. The Dunedin Study enrolled 1,037 babies born in 1972-73, and more than 90% the participants are still enrolled and continue to participate in periodic health measurements. Among the data gathered over the years are biomarkers for changes in heart, kidney, lung and immune system functions, as well as dental health, mental acuity and physical abilities. Duke researchers, in earlier studies, used nineteen distinct health factors collected regularly among this group to establish a means of measuring the biological aging process. By assigning an aging rate to the study group based on the biomarkers for organ health, the researchers found that some of the 45-year-olds aged at a rate that was slower than average for their chronological age. These slow-aging participants looked younger (their faces had fewer wrinkles), they remained mentally sharp, their cardiovascular health was good and they continued to walk at a brisk pace.
On the other end of the spectrum were 45-year-olds who aged more rapidly.
These people looked older, showed signs of cognitive decline as measured by IQ scores, felt less healthy and even tended to have pessimistic attitudes about aging. By midlife, people who had aged more rapidly were already at risk of developing frailties that impair physical and financial independence.
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[gabrieltorres]

Oh you don’t have to tell me, I started my anti age journey just last year Oct, I’m 40 years old and now I’m down 60lbs and reversed sleep apnea by changing my diet to a Carnivore lifestyle and taking just the right supplements I now feel and look like I’m 20 again.
Following the anti age community has helped significantly as I am following all of their advice and this craziness is working. Craziness as in the science, clinical trials, anecdotal evidence and now my personal experience...
It’s true, all of it...

[tomrobertson]

I'm 65 and have been seeing my classmate deteriorate over the years.
First oxygen mask and tank at 45 .
By 55 I saw more walkers being used
Now at 65 it's sad to go shopping in my hometown.
Because seeing so many that look like they are 80

[lawnmower]

Very informative; agree that taking proactive steps by your 40’s, incl intermittent fasting, cut inflammatory foods, increase exercise, add supplements, possible hormone therapy and “thinking young” and staying active are all important IMO

[elliottrubenstein]

Savannah greetings Vincenzo. Appreciate your hard work, “do not go gentle into the night”, or something like that that somebody else said. 75 with Cancer, no aches, no pains, feeling great. Me and Tony the Tiger.

[Pluvofor]

It's amazing how useful the Dunedin study has been in so many scientific fields.

[MsSilkyJuneja]

This information is transformational . Thankyou Vince

[englishcoach]

Thanks for the content. We certainly dont have enough people as inquisitive and prepared to contribute to the longevity question.

[thomaspinches]

Aubrey de Grey has interesting views on how governments will incorporate preventive medicine on a population level. Basically, it will get to the stage where govts can't afford not to implement population-wide anti-aging interventions. Clearly we're not there yet, but it's an exciting prospect.

[littlevoice_]

I think we should all be offered a longevity health check when we get to the age of 35. It should include in depth biomarkers, epigenetic, heavy metal exposure, diet analysis, microbiome, cognitive health as well as the general waist circumstance, hgA1c and cholesterol ratio to Triglycerides. Then we can make meaningful targeted changes to reduce age related diseases. The results could also act to motivate important healthy lifestyle changes.

[noname-nuoo]

Wow this should be talked about more often

[scotlandtheinsane]

People might age differently but I do NOT think people in their mid-forties should ever have 'assisted living!
Especially when things are going precisely the other way now.
Too bad if they have aged more, make investments into your own health and improve it.
Reverse the aging!!!

[manuelojeda]

I'm I. My late 60's and I walk in fast pace. I have very little wrinkles. I take hydrolyzed bovine COLLAGEN. Strawberries with plain yogurt. Intermittent fasting too. I eat Wild CAUGHT Salmon. I Put a lot of dried PARSLEY in my food.

[maarten]

It's interesting - many people who are my age I see as old enough to be my mother or father. I don't relate either on a physical level or mental-attitude level. I've been athletic for most of my life but also had 10 horrific years that were beyond description. I do get depressed at times (and have been battling depression all my life) but I am still open, curious, and always learn; am still flexible and strong; and love to laugh (I think my sense of humor has saved my life many times.)
I have become much more interested in diet (and how it relates to aging) in the past few years, although my diet has always been really good. I'm definitely much more into supplements and started practicing IF this year.

[euanmclaughlan]

Great content Vince I started my life changes and supplements at 46 and glad I did was already very active and doing most of the right things, but never prioritised sleep until recently after seeing the science, have you heard of the new sirt6 activator from donotage I've just subscribed to it and I'm waiting for delivery, I watched Vera Gorbunovas presentation on her work with Naked mole rats with Modern healthspan, some great work being achieved and looks like a great molecule for DNA repair

[lionnotsheep-]

I am following your channel for some time and implemented a different healthy lifestyle (with supplementation) based on David Sinclair findings, successfully into my life. One major change is obviously raising our NAD levels with supplements. I have seen numerous videos about different varieties raising NAD with for instance: NMN, NR, NIACIN or Apigening but I haven't found anything about NAD injections.

[Peacelovefreedomvibes]

Hi Vince can u do a video on: wht I wld do if I have cancer.
My sis has been diagnoised with stage 3 bladder cancer...doc says 5 years to live if chemo. She is not taking the chemo route, she is fastg, no carbs n animal proteins n doing infrared saunas 4 times a wk. Taking tumeric, mostly organic meals, Vit D, VitC....etc
There is no IV vitC, ozone therapy availb in my cty....only the usual slash n burn therapy( chem, radiat)

[lakshmishrivastava]

Hi vince. I am from India. Am finding it difficult to get a reliable source for nmn and resevetrol.. could u please suggest

[arielmalanga]

"Do not grow old, no matter how long you live. Never cease to stand like curious children before the great mystery into which we were born.”   ~Albert Einstein