LONGEVITY: The Science of Aging and How to Turn On Your Longevity Genes to Live Longer

Dr. Rajsree Nambudripad, MD is board-certified in Internal Medicine and founder of OC Integrative Medicine in Fullerton, California. In this video, Dr. Rajsree explains the science of aging and all the factors that affect your longevity, from genetics, to diet, exercise, exposures, and lifestyle. What's the difference between Lifespan and Healthspan? Biological Age vs. Chronological Age? What are the hallmarks of aging? Learn about Sirtuins, AMKP, and mTOR, and Autophagy and how they impact your longevity. How does the gut microbiome impact your Longevity? How does chronic inflammation affect Longevity? She reviews the latest science on Diet, Lifestyle, and Supplements to promote health and longevity.

00:00 Introduction
00:42 Lifespan vs. Healthspan
01:31 Outward Signs of Aging
01:57 Proactive and Preventative Approach to Health and Longevity
02:20 Key Lab Biomarkers
03:45 Chronological Age vs. Biological Age
04:18 Supercentenarians
04:31 Factor Influencing Longevity
05:03 Hallmarks of Aging
08:23 Epigenetic Clock
08:59 Sirtuins, AMPK, and mTOR
13:30 Autophagy
14:58 Time Restricted Eating
16:00 Gut Microbiome and Longevity
17:19 Inflammation and Longevity
17:48 Inflammaging
18:43 Sugar and Advanced Glycation Endproducts
20:18 David Sinclair, PhD and Information Theory of Aging
20:48 Yamanaka Genes (Fountain of Youth Genes)
21:14 The Future: Gene Therapy and Senolytics
22:22 Blue Zones
23:47 Diet: Key Principles
25:35 Intermittent Fasting
26:31 Exercise
27:20 Hormesis
28:09 Supplements to Improve Your Healthspan
29:53 Berberine for Insulin Resistance
30:42 Sleep
31:02 Minimize Exposure to Toxins
31:44 Relationships with People
32:17 Case Example: Mike
32:40 Key Points

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➡️ Watch Dr. Rajsree's video on Insulin Resistance (Paleo Diet):

➡️ Watch Dr. Rajsree's video on Clean Keto Diet:

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This information, including but not limited to, text, graphics, images and other material contained on this video and website are for informational and educational purposes only. No material in this video is intended to be a substitute for professional medical advice, diagnosis, treatment, or medical supplement approved by the Food and Drug Administration. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician. Never disregard professional medical advice or delay in seeking it because of something you have seen in this video. No physician-patient relationship is created by this video or the information provided. Furthermore, neither Rajsree Nambudripad, MD or any contributor to this video, makes any representations, express or implied, with respect to the information provided herein or to its use.

[drrajsree]

Thank you everyone for watching! I look forward to reading all your questions and comments, so please post them below! To learn more about any of the supplements described in the video, see link below:

[elizabethk]

I am 75, and feel better than in my 40s. No meds, no aches or pain. Never had any surgeries or hospitalizations. Eat wisely, and exercise regularly. Keep negative people at arms length, and live a life of gratitude.

[anilsagar]

Probably one of the best videos on healthy life style

[ericeichstaedt]

Just a general comment, I'm a health nut and it's my favorite subject, and since discovering your channel you are now my new health guru I follow. I have very high standards, so this is saying something!!! Thank you immeasurably!!!

[oanairani]

I've watched hundreds of videos from all the doctors on youtube.
You've done an amazing job by condensing all the available science on this topic.
You are a gem, thank you so much for putting all this info together. ❤️
If all doctors were like you, we will be a much healthier society.

[didahuka]

I have followed many anti-aging materials but this is the most comprehensive one.Thank you I will watch repeatedly.

[markcosgrove]

You are brilliant. You remind me of the saying " There is always something that you can do before you see your Dr.".

[ssmurtyguda]

This is one of the best videos on longevity I head so far. I'm 75 now. Unknowingly following your advices so far like eating veg food, sleeping, interacting with a network of relatives and friends friends, moderate exercise on bed only for1 hr daily etc. I am glad as you confirmed my habits are good in your seminar.Thanks Dr.

[lilytea]

0:12: ⏳ This video discusses longevity and how to live a healthy life.
5:01: 🧬 The video discusses the factors that contribute to aging on a DNA and cellular level.
9:43: 🧬 Sirtuins are enzymes that unravel histones and regulate gene expression, but their activity declines with age due to diminishing NAD levels.
14:30: 🍽 Fasting and calorie restriction promote longevity by activating autophagy and improving lifespan in various species.
19:07: 🍭 Minimizing sugar intake and foods that quickly turn into sugar can help in looking younger and living longer.
24:01: 🥦 To live longer, it is important to follow a customized diet that includes whole foods, limits refined sugar and processed foods, and focuses on plant-based sources of protein.
28:53: 🔑 Omega-3 fish oil, magnesium, antioxidants, and berberine are recommended for various health benefits.
Recap by Tammy AI

[healthhollow]

I think this video was possibly the best I’ve ever seen on health and longevity! Thank you for covering all aspects for us🥳🎉

[wmp]

All family doctors should watch this video ❤

[naazmahkatrina]

This video was like gold.I think that this is the proper way to do.Thank you very much doctor.

[bbldb]

I’m sure I am aging backwards. At 65 I was horrible and sleeping 4 hrs in the middle of the day. Fat and all metabolic markers were way out of range. But when my Pre Diabetes had advanced to #2 diabetes, that got my attention. Today at 75 I feel great and my metabolic health proves it. 80 lbs gone and I ride a electric Unicycle for transportation and I high intensity sprint. And listen to Doctors like you!

[damtewmekke]

All I can say is thank you for sharing your knowledge on healthy life style.

[craigt]

This sums up everything really nicely. I wish more content creators would do this. Instead, they insert memes, give shot-outs, engage in rants, insert sound effects, and just generally waste a lot of time. This video is just the opposite and worth listening to multiple times.

[NZT]

This video simply summarized everything about the field in a simple way that anyone can understand. How's that possible?

[patmackay]

This is the best video I have seen on longevity!!! I just subscribed to your channel. There are several other videos that I want to watch. Thank you Rajsree.

[josephdappa]

Dr. R.N. This TubeTube is the best I have ever listened to. I want to download your YouTube on my phone. Thanks indeed. JD.

[Sofia]

It is great that more people get to know through your videos that lifestyle is the key to longevity. Thanks for posting!Thanks Dr.

[lorenacarlson]

I watched dozens of SIBO videos and I discover Dr. Nambudripad's videos which are the ones that makes more sense than any other. I watched her SIBO/IBS/SIFO video's and her giddiness is what has been working for me, unfortunately I am on antibiotics at the moment since I my issues got to a significant level. Now I am seeing the light at the end of the tunnel and hopping that there is no severe damage after antibiotics. Thank you for these amazing videos Dr Rajsree. Now, I need to start thinking on supplements and pre/probiotics, the question is, how am I going to know that these products are good quality? Please, no offense, but I bought so much product and nothing work that now, I am so skeptical of everything. Maybe nothing work because I was doing everything wrong until this channel .... Any comments about the her products will be appreciate it. Thank you again. 💚