The Science of Looking Younger, Longer | Lifespan with Dr. David Sinclair #6

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

#DavidSinclair #Longevity #SkinCare

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Timestamps:
00:00:00 Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair
00:02:54 Estrogen, Progesterone, and Menopause
00:09:51 Thanking the Sponsors
00:12:57 The Pinch Test, Epidermal Thinning, and Foot Ulcers
00:18:29 Skin and Biological Aging
00:23:19 Cellular Senescence, Ultraviolet Light, and Skin Aging
00:28:15 Collagen, Keratin, and Skin Health
00:33:38 A Quick Aside about Nails
00:34:45 Autophagy and Retinoids
00:36:57 Resveratrol, NAD Boosters, and Hyaluronic Acid
00:41:44 Botox, Skin Peels, and Microneedling
00:43:28 No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food
00:45:42 Hair Loss and Hair Graying
00:49:45 Topical Treatments, Pills, and Dihydrotestosterone
00:55:19 Frickin Laser Beams: Low-level Laser Therapy
00:57:59 Platelet-rich Plasma (PRP) Injections
01:00:11 Hair Aging, Stress, and Gray Hair Reversal
01:06:11 Targeting Aging Upstream
01:07:37 Today’s Takeaways
01:09:25 Subscription and Support Options

Links:

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

[FortniteKingClips]

David inspired me to go to college to study molecular biology and aim for a career in fighting aging because I heard of him from the podcast he did with Joe Rogan in 2019. Thanks David!

[Keira_I_AM]

People often tell me that I don't look my "age" (in my 50's). I pay attention to eating (organic, mostly vegetables), exercise regularly, don't drink alcohol, don't smoke, take supplements and use organic skincare products. David Sinclair speaks volumes of truth for anti-aging in this video and appreciate his scientific logic.

[audiosmarts]

28:22 Keratin & Collagen
34:50 Retinol and Retinoids
55:30 Low level laser therapy
58:15 Platelet rich plasma
Gdf15 - Hair growth gene
Tretinoin - Medication used to treat acne and sun-damaged skin

[strictlyprivate]

Prof. Sinclair looks younger now than he did five years ago by well over 10 years. Fantastic!!! Resveratrol and NMN outstanding results

[daveoatway]

Great show. I have been using 1-Skin for a year and have noticed a difference in my skin. At 77 years old, my Pinch Test is very quick. I started taking NMN 3 years ago and noticed my hair getting brown again. This is increasing. Now I take 2 gm of NMN most days (i figure I am older and need all the help I can get) and walk 5-10 miles almost every day, with some HIIT. I'd be very interested in an update on Dr. Sinclair's father's journey. These shows are excellent - much better than many interviews with often clueless interviewers.

[irenhollo]

Dr. Sinclair, as a Hungarian admire your work! A proud Mother of a Harvard Student! Your podcaste is enjoyable... and easy to understand! Please keep it up! Thank you for your work!

[siamsiraji]

Dr Sinclair has been an inspiration for me. I have heard of him back in 2018 for the first time, since then been following all of his work. Now, this year I will be graduating from the dept. of Biochemistry and Biotechnology. Currently, I am working on one of the sirtuins genes. All because of Dr Sinclair. You made this young boy dream big. I just turned 23 this year. Haha.. and I have decided to pursue this longevity field. Thank you wholeheartedly, Dr Siclair.

[traceyleigh]

I love this podcast. I am almost 53 but feel 33. And apparently look more like 43. Vegetarian, yoga and meditation has been good so far but this is amazing information. I was a late parent. To know I have to power to live long enough to see grand kids grow up is amazing. Thank you both for all that you do. 🙏 And I love the humour. 🖖 😆 Aussie Gratitude being sent your way 🇭🇲

[drkaushikt]

As a doctor, this is one of the very few podcasts I genuinely look forward to

[JeffNixonComedy]

Black coffee and Sinclair podcast... the new Wednesday morning ritual

[thatstheguy]

David reminds me of that friend who got stoned for the very first time and when they talk they have this look/smirk on their face where they’re about to burst into laughter over absolutely nothing at any given moment 😄

[PandaA-cvmm]

Thanks for this. My mom has used retin-a since she was about 25. She is over 70 now. No skin cancer or other crap…. Her skin rocks!Very incredible info. Lots of love ❤️

[ptyh]

Dr. Sinclair looks really young for someone who is 52! I was watching his interview with Lewis Howes and it was really inspiring! I feel like it's something to do with our hormone change that age us as we get older

[NicholasOdinson]

My new favorite podcast! Hope you keep it going after 8 episodes.

[kellysober]

I have been following David’s work for about 2 yrs now. Thank you for addressing women. You do have women listening. It does seem like women get left out of the coversation, out of research and their health issues (like autoimmunity) don’t get money and attention. It does feel like wr are second class honestly.

[ThisArdentLife]

Please do not shy away from talking about female concerns just because you aren't women. You don't have to have a uterus to understand the science of how they work! This approach runs the risk of leaving women in the dark. Please address our aging concerns equally. Thank you for the great info. I love your show!

[gloria]

ITS REMARKABLE HOW DR SINCLAIR HAS STAYED SO POSITIVE AFTER ALL HE HAS GONE THROUGH TO ME THIS IS ONE OF HIS MOST HELPFUL MESSAGE

[indiegold]

Here is why everyone should listen to D Sinclair...glowing white teeth, looking 30 at 50+, bone structure. BOOYAH!

[crazyfarmgirl]

I am thankful for your podcast i am trying to soak up all the health and antiaging information i can. So that i can age well, both physically and mentally. I want to be an old person who can take care of themselves and have a full active life not requiring aid from others.

[Plumpers]

Using my red/infrared laser light while I watch this on my head and face. It's really helped me with my brain fog left over from having COVID a year ago