How To Get Fallout 4's Rarest Chem

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What's your favorite Chem to use in Fallout?

bear
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There are so many good chems. My usual cocktail is Calmex Silk, Bufftats, Orange Mentats, Psychobuff, Jet Fuel, and Overdrive, washed down with a Dirty Wastelander.

ms.aelanwyr.ilaicos
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I love how a drug can make you more lucky as if it changes the universe

TheRealMrMan
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I need to grab this on my stealth survival playthrough

sly
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Fun fact, you can get two X-Cell super early on in a building in Concord!

ImJustBag
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Also sold by the drug dealer arguing with Trudy.

TaxEvasion
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I'd say the best chem is leveling up, to where nothing is a threat to you.

CraftierUD
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As wild as this sounds. I never really use chems. Of course I've done the random like "oh my God take everything now so you don't die" but I never go out of my way to make it a regular thing.

gagesons
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I do love a good junkie play through. Something about the idea of waking up from a 200 year nap and immediately shooying up or huffing every strange substance found in the pockets of the many raiders you kill is endlessly hilarious. Add melee only and youre in for a real proper murder hobo experience.

homunculusgrey
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Sorry but it's psychobuff all day every day.

DevotedSin
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Am I one of the few who just don’t use chems? I’m 60 hours into my Fallout 4 playthrough right now and only just popped my first buffout for 2 minutes of 20 carry weight

SomeSlushies
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If you spam the aim button while in 3rd person with a full auto gun some will double the fire rate when spamming the aim

waffle
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To what?! I'll have access to what?!

Amzuro
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Everyone talking about the best chems but completely glossing over Grape Mentats and X-Cell is crazy. And before you say that X-Cell is super rare, there are quite a few set spawns that you can run and grab as often as you'd like.

ThereIsNoWifi
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I myself like Bufftats and PsychoJet, that shit hit different on survival.

Sir_MMMMMMMMs_a-lot
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I unintentionally used the bear head for like 70% of my play through and didn’t think anything of it because I’ve watched so many of these shorts

geese
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Man I hope I get to live through a nice period in my life, its weird when everythings going great in your personal life but you feel like things could be better. Nostalgic for a time that never really existed I guess.

t.rellis
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Day tripper and mentats are a fun combo, the different flavors make the screen a different color and with the day tripper it just accentuates that

Chilldude
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I rarely use any chem, probably a few grape mentats once every while to lower trade costs. The only time i intentionally use combat chems is to farm Cait’s affinity before curing her addiction.

m.rak
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Huh. I’ve never even heard of this. I don’t do chems though

youtubersdigest