Ketone Bodies (Part 1 of 4) - Intro

In this video, I give brief introduction to ketone bodies, describing what they are, what their purpose/function is, and where they are made.

There are three Ketone Bodies: Acetone, Acetoacetate, and D--Hydroxybutyrate (structures shown in the video). They are all made in the mitochondrial matrix of liver cells (hepatocytes) from Acetyl-CoA (from beta oxidation) that built up due to lack of flux through the Krebs Cycle. Acetyl-CoA, being an activated 2-carbon unit, does not hang around very long, and if it’s not going through the Krebs Cycle, it’s diverted off to Ketone Body Synthesis, otherwise known as Ketogenesis. Between the three ketone bodies, acetone is produced to a lesser extent, while acetoacetate and D--Hydroxybutyrate are produced to a greater extent. Ketone Bodies function as an energy source for extrahepatic tissues, meaning tissues other than the liver. The liver produces ketone bodies to be sent in the blood to be used by other tissues. Even the brain, which prefers to use glucose as its sole energy source, adapts to using ketone bodies for energy during starvation.

Don't forget to LIKE, COMMENT, and SUBSCRIBE:

[medichelp]

One of the 2 best Channels regarding Biochem !!! Keep it up - U really are helping Medic studentes!!

[ranijubran]

Moof Uni ... You are AMAZING man, you made biochem look a lot easier, your vids have helped me so much

[adwoaagyei]

Great Video! I have watched a lot of your videos especially for Biochemistry and I find them to be very helpful. Thank you!!

[cindyadams]

Need more general videos on ketones that do not go right into the ketogenic diet.

[NexusEden]

Always happy to see your videos, just wish you could boost your audio a bit...I always have to turn my volume up really high and then get blasted by the next video or commercial. You should also add a link to the next video.

[gesundheit]

loved it, liked it, subscribed, and if anyone i know needs a ketogenesis video ill recommend this (: .. gonna play part 2 of 4 now

[noranmohammed]

thank u
that's really simple explaining and helpful
keep going 👍

[Farah_Saad]

Thank you so much.... That was helpful : )

[evanabajjali]

Extrahepatic: u means that the liver doesn't use ketone bodies for energy?

[doloresvalenzuelagranados]

tendria k esplicar. K se puede y no comer. Y si se toma. Antes ho desues de las comidas. Hoy me lo entrego el mensagero..

[daviddikeman]

Brain uses ketones not just in 'starvation' but also in low carb diet. Buy a ketone meter and try it some time!