Methylene Blue is Neuroprotective After Ischemic Injury (Mouse Study)

Methylene Blue is Neuroprotective After Ischemic Injury

A quick review of the mechanisms demonstrated by methylene blue studies for MB's neuroprotective role in animal models.

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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

URL list from Thursday, Dec. 1 2022


The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core | PLOS ONE

AMPK - Legere Pharmaceuticals

Schematic illustration of the mTOR signaling pathway. AMPK indicates... | Download Scientific Diagram

Model of the AMPK and mTOR signaling network in mammalian cells. AMPK... | Download Scientific Diagram

Frontiers | Protection against neurodegeneration with low-dose methylene blue and near-infrared light

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation | Translational Neurodegeneration | Full Text

[eileenbrookfield]

I started taking Methylene Blue on May 1, and my multiple sclerosis bout that I have been going through for two years disappeared. I’m walking and bending my legs. It’s been a miracle for me.

[violetiboya]

I ordered MB based on this video (been watching this channel for 2 years and greatly appreciate all your content!). Today is day 2 and I am blown away at how much better I feel. I was diagnosed with fibro, asthma, etc decades ago...I can think clearly without coffee jitters, my pain level has dropped dramatically and I finally don't feel like I have the flu 24/7. This is amazing! Thank you so much for sharing this information. I would never have learned about MB if you hadn't discussed it! You are greatly appreciated.

[bbldb]

I’m 76 now and also vary healthy but 6 years ago I was a metabolic disaster. Now I have even started driving again I stopped 5 years ago to be safe. Been doing low dose MB and my mood and cognitive function is vary improved. There’s more but Mb matters.

[SuperFrankieKimm]

it's working!!! I started taking one 25 mg capsule daily three weeks ago. I've had CFS, brain fog, nerve pain (and many other symptoms post vax) for three years. within a week of taking MB, I began to feel more energetic. I can feel my brain coming back online! I have no nerve pain. I feel better than I have in years. I'm super emotional as I write this; so many people, suffering so badly, finally getting help...it's overwhelming. I love you, dr. been. I feel so much for the people who commented and shared their stories here. thank you all. ❤

[randallhesse]

I'm here just re-researching methylene blue. I thought I remembered that this is the compound to give quickly after having a brain injury to keep the brains ability to recover. I was right, this is the compound every soldier in war should have on hand for his fellow man/ or woman.

[hondablack]

As I understand it, one can have a lot of underperforming neurons. If one takes MB, it can 'recharge' those cells, resulting in increased ATP output. Hence reconditioning old brain cells. As I have been suffering from Lyme disease and probably missing a lot of mitochondrial function, I have just ordered some Methylene Blue to experiment. Wish me luck people.

[risecopeman]

CELEBRATING!! Thanks to people like DrBeen, the commenter's input, the doctors and researchers that have kept open minds, and other high quality youtubers exercising freedom of thought and speech.... MY DAUGHTER'S BLOOD PRESSURE AND HEART RATE ARE NORMAL UPON STANDING THIS I couldn't have figured out what to try or who to work with if it hadn't been for all of you. We will probably never meet, but I am thanking God for each one of you. This horrible thing may not be over, but we are getting there! THANK YOU AL! Thank you especially, DrBeen, for info about FLCCC, Dr. Patterson. Just responding to me helped me not give up even in my worst moments of a heart broken mom.

[michelemcneill]

I have ME and normally get sick all the time. I've been on methylene blue for about 3 months and haven't been sick once.

[totallyautonomous]

🎯 Key Takeaways for quick navigation:

00:13 ⚠️ Dr. Mobeen discusses methylene blue side effects, contraindications, and cautions - important to review before considering use.
05:14 🧠 In ischemic brain injury, methylene blue interferes with p53 activation which reduces apoptosis, providing neuroprotection.
08:58 🧹 It also enhances autophagy, helping clean up cellular debris in injured neurons.
15:08 🩺 The study authors suggest emergency responders could administer methylene blue on-site to protect more acute stroke patients.
23:16 🔋 As an electron cycler, methylene blue can kickstart dysfunctional mitochondria in ischemic tissues by donating and accepting electrons.
29:32 💊 This makes it an antioxidant, anti-inflammatory, energy enhancer, and nitric oxide producer, conferring neuroprotection through multiple mechanisms.
36:13 📝 In summary, low dose methylene blue may help rehabilitate mitochondria, reduce apoptosis, trigger autophagy, and protect tissues in various conditions.

[donnafraenkel]

Can't recommend this enough ❤i give it to my dog in her water (micro dosing) and her health is back to being like a puppy. She's hipermobile and her joints and bones are very fragile, and since taking it, she not showing signs of any pain or discomfort, and her coat condition has improved. She also has teeth issues and bad breath which has almost disappeared

[juliafisherlmmortalbeauty]

I almost stopped taking MB as l have read that it is direct NO blocker. After watching this l have learned it is actually the the opposite!! U are so knowledgeable! I love the way u explain everything in a way l can absorb the amazing knowledge and information that u share! Thank u! Xxx 😊💖 xxx

[GoldenBlaisdale]

I know this is my third comment, and I apologise if it’s annoying, but another really important thing to take into account is the purity of the MB:

There are three different grades of methylene blue:

Industrial grade – used to dye fabric

Chemical grade – used in laboratory experiments

Pharmaceutical grade – used to treat methemoglobinemia, urinary tract infections, overdoses, and considered safe for human use.

By the way, the methionine blue that you will find in fish shops for treating fish diseases is not pharmaceutical grade.

[ketherwhale]

Methelyne Blue could be used in Sepsis. It works with Alzheimer’s and has probably the capability to help in Parkinson’s like Michael J. Fox.

[miriaml.]

Thank you for this fantastic explanation of the mechanism of methylene blue! I agree that every emergency medical professional needs to have a vial of this ready to go. It's not a questionable treatment! And as long as the doses are low enough there would be very small number of times when it wouldn't be safe.

I started out in healthcare in 1982 and have learned that mainstream medicine has its benefits, but it certainly has many limitations. I'm not aware of any pharmaceutical that can do this. We all know why that is. I'm talking about there being no profits in it. But that doesn't translate into meaning that there is no use for it because it is astonishing what it can do!

I recently stumbled on it looking for something else, as often happens. I decided to use myself as a guinea pig because I have some conditions that I felt it might improve. I don't believe it was wishful thinking when I say that's after one dose got my thinking felt much clearer. As I continue to just take small doses my clear-thinking has persisted! That's saying a lot because I have had depression and anxiety for about as long as I have been a healthcare professional. And I have been willing to try almost anything including clinical ketamine IV treatments which didn't help me at all. That should tell you how desperate I've been.

I'm going to kiss my bottle of methylene blue as you jokingly mentioned! Thank goodness it's not a joke. 🎉

[mikeward]

Impressive: prevents neural apoptosis, protects mitocondria, and activates neural autophagy (perhaps in other cells too)! (May the force be with you. ;^)

[fragranthills]

Your videos are priceless, like a Stradivarius. Your drawings make your comments understandable to non-physicians. I, therefore, bought your lifetime membership and I bought pharmaceutical grade MB. I addition, I bought one for each vehicle in my family.

[MarcusAurelius]

I love your sense of humor in selling access to your lectures. 1/2 the price of a bottle of MB!!!!

[michelemcneill]

I have ME/CFS and started Methylene blue 2 weeks ago. I have more energy, less brain fog. I take 3 drops =1 1/2mg in morning, 2 drops at noon and 1 or 2 drops in the evening. I'm sleeping better than I have for years.

[Storm_Lily]

This is such a beautiful video! I've watched SO MANY MB videos, and this one is easily the best. Thank you!

[BeYourUniquePotential]

Hello Dr Been, I love your teaching style. I’ve been taking MB for two weeks now after having a suspected tia/Bell’s palsy last year. I sleep do my well and I feel so much clearer in my mind. Thank you ❤