CRISPR-Cas9 Genome Editing Technology

We've learned about a few techniques in biotechnology already, but the CRISPR-Cas9 system is one of the most exciting ones. Inspired by bacterial immune response to viruses, this site-specific gene editing technique won the Nobel prize in chemistry in 2020, going to Jennifer Doudna and Emmanuelle Charpentier. How did they develop this method? What can it be used for? Let's get the full story!

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[cyrenedomogalla]

How far we've come in just my, as yet short, lifetime. As a teenager they were still mapping the human genome. Now we've figured out how and where to edit that genome to solve diseases.
Caution is warranted, but I wish more people were impressed and inspired by this than afraid.

[applepen]

this video was so 'CRISP' and clear. absolutely loved this, thank you sooo much! Keep making such videos <3

[keithyagami]

I have a molecular biology exam in 40mins

[zopilote_]

this is amazing, the fact that bacteria developed this over millions of years. and that humanity has understood it enough to use it to solve problems

[angelisvegan]

I'm so fascinated.. I'm a premed and studyin to crack the first entrance exam but i never thought that everything I'm learning is so amazingly wonderful .. it's so vast .. like how do these chemicals know what to make and what to stick to..and who to interact with... it has to do with reactions.... i didn't know that things I'm learning is not just a part of a chapter but rather a part of me..part of my beloved environment... so important and fascinating .. but i don't give em the respect they deserve..

[PurpleHonee]

Excellent! I was just coming up to my Clinical Genetics final and this was one of our last topics. It helped a bunch! Wish me luck.

[RohitPant]

This modular explaination by you makes the biomolecular mechanism behind CRISPR look easy. Thanks!

[vickyr]

My son is a monoculture genetic scientist. He was mentioning recently that he was going into this specific study. Right on track and not worth explaining to people like you.

[frozendaffodil]

Thanks for making this video! I'm currently in high school and I'm super interested in things genetics related so I'm super grateful to have encountered this video with simple enough explanations for someone like me!

[envirotrax]

Best explanation of gene slicing that I’ve seen so far.

[sevmpjt]

It's a technology that I couldn't understand well even if I read a related book, but after watching this video, I was able to understand Crisp's concept properly.

[dreammix]

Whoa!! That that was a lot of information! I'll have to watch this a few more times before I really get my head around it

[cristianodelgiacco]

That video was amazing. Thanks for helping all of us as always Professor Dave.

[unheardsoul]

Professor Dave as a Indian student I would like to know the ways and techniques which you use to understand these complex topics . Moreover I would like to know the books you study for your knowledge of subjects like physics, Chemistry, chemistry .
Your knowledge is free of cost and most importantly it's best

[phoenix]

Better explanation than any so-called coaching institute. Thank you so much for making this simple 🙏

[Tchpat]

Thank you for finally making me understand the actual mechanism of the Cas9 protein. I'd love something on the pros and cons of NHEJ vs. HDR processes if you ever find the time to make a video about it!

[charlesakhimienmhonan]

It was effective in curing 22 of 45 Sickle Cell patients in a recent study. The patients are still being observed for close to one year now. If it succeeds, it will revolutionize medicine. It seems to be working now as 49% rate, if maintained, can be improved upon.

[rickkwitkoski]

Wow! It is amazing what we have uncovered. Being able to edit genes themselves is one of the most powerful medical tools we can have.

[jameshopkins]

I learned of this several years ago, and am familiar with the work of Jennifer Goudna. I have a degree in Microbiology. Prof Dave has done very well covering this, and I now am learning much more.

[santinonanini]

Very good explanation. Much better as the courses that I followed in my master’s degree where I needed to read tons of articles to get to this point. Thank you very much, please continue biotechs videos.