Dimethyltryptamine [DMT] | Biosynthesis, Mechanism, & Metabolism

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[spacetoad]

you should definitely do a similar video for mescaline or other phenethylamines or mdma or thc

[Viva-La-Lexy]

It was shockingly hard to find this sort of information regarding DMT on the internet. Thank you for making this video!!!

[joshuabolin]

This is great but didn’t some recent studies show that DMT is found in pineal glands of mice and the brains, liver and lungs of humans? Wouldn’t that mean that it’s biosynthesized in mammals?

[axlrosegnr]

You lost me in the first 50 seconds when you incorrectly stated dmt isn't found in mammals.

[Ridingshotgun]

"DMT is not just in plants, but also can be detected in mammals, " says Jimo Borjigin, Ph.D., of the Department of Molecular and Integrative Physiology. Her interest in DMT came about accidentally. Before studying the psychedelic, her research focused on melatonin production in the pineal gland.

[skeetlejuice]

Great video but mammals do make dimethyltryptamine and also it's not pulled from the leaves it's pulled from the root bark

[antoniomele]

Thanks for the information! Love your videos

[eyeofthetiger]

I'd be really interested if you did a video on 5-meo-dmt.

[StevenLeMieux]

I will be that guy and throw the curveball out here. Even if you're using a scientific approach anybody who's dabbled in dimethyltryptamine knows that it goes much deeper than that way past a neurological or biological mechanism. That being said look up the sacres secretion and once you're done digging through the garbage and actually find some solid research or the effects come back to this video and connect the dots. It's in everything we're unaware of it because of our diets and lifestyles. This theory has been tested if you line up a specific time of the month take bioplasma cell salts prior for an extended period and literally flush your system by not eating for a few days and then ingest dimethyltryptamine the effects go way past a simple trip... But don't take my word for it just some friendly advice.

[looneycrow]

Psilocybin has built in maoi which allows it pass to the liver

[brentnicol]

I am doing a presentation/ powerpoint on Ayahuasca and am wondering if all of this is the same because Ayahuasca contains a MAOI.

[jxhnny_gxddamn]

Pretty sure it works in a similar way In humans

[maxwellpruett-nyes]

What if you take dmt orally without maois or some sort of metabolism agent's?

[dhaktizero]

which p450? im curious what the effects of a suitably short acting inhibitor (or higher affinity substrate) of the p450 and then a reversible mao-a inhibitor and .5mg/kg of dmt all together would do.

[michaelscott]

I appreciate how informed we are with these substances at a chemical level. At the same time, people that choose the synthetic version are not taking this medicine the way that nature intended. If you're just chasing a high, then I understand. If you want a real experience, you need to try the natural version. A "bad trip" is what you NEED sometimes... Those are the most enlightening experiences. You can't pick and choose at a chemical level and expect a breakthrough. Those other molecules are necessary to be grounded ultimately to this world in my opinion. I've had a "bad trip" twice, and now I only prefer the natural medicine since I got most of the previous trauma/ego already done with. You are NOT doing 5 meo dmt if you are taking it synthetically, you need to experience "bad trips", in order to reach the next level naturally. Synthetic version eliminates all the nature, and you are within your thoughts only in a way. A so-called "bad trip", is the best trip and you need nature's presence so in my opinion, you need to try the natural version.

[Alex-hglq]

Which major would this fall into? Pharmacology, biochemistry or organic chemistry?

[toxikspeaks]

You know over the years i have had a good bit of experience with Dmt. Now there is something about this drug i would love to study.

I would love to study DMT'S potential as treatment for headaches, I know it sounds weird but i have never taken something that worked so well at getting rid of headaches. I had one of the worst headaches in my life, Did some dmt and that headache was 100% gone when i came back. It was a miracle my headaches are dehabilitating, usually only opoids + nsaids can cure them

[lukes]

“the mao inhibitor is normally natural or synthetic.”

[alkeryn]

one could imagine bioengineered yeast or bacteria to produce it.