Can DMT Inspired Molecules Rewire Your Brain?

Psychedelics such as DMT have been hyped as wonder drugs for the treatment of depression, PTSD and other mental illnesses. This video explores the science of compounds inspired by DMT that were designed to promote neuroplasticity and an overview of the pharmacology that underlies their mode of action.

Work published by:

Lee E. Dunlap, Arya Azinfar, Calvin Ly, Lindsay P. Cameron, Jayashri Viswanathan, Robert J. Tombari,Douglas Myers-Turnbull, Jack C. Taylor, Ana Cristina Grodzki, Pamela J. Lein, David Kokel and David E. Olson*

J. Med. Chem. 2020, 63, 3, 1142–1155

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References:
J. Exp. Neurosci. 2018, 12, No. 1179069518800508. (Psychoplastogen overview)
Cell Rep. 2018 June 12; 23(11): 3170–3182 ( Effect of Psychedelics on Neuroplasticity)
Neural Regen Res. 2015 Apr; 10(4): 559–561. (mTOR Role in Dentrite Growth)
Neuron. 2014 Oct 22;84(2):275-91 (Neurology of mTOR)
ACS Chem. Neurosci. 2016, 7, 6, 767–775 (Multiparamater Optimization)
Cell 2017,168, 377−389 (LSD-Bound 5HT2 receptor)

[brandonchapman]

Wow this is by far the coolest science happening right now. So much potential

[kolzkrd]

The Olson lab's research is so interesting. I wanted to join them for my PhD but unfortunately got rejected, but I will continue keeping up with their research and maybe some day I can get in on it.

[maryannebrice]

Have been doing psychedelic DMT breath work daily for 20+ days! I have bipolar and have been under acute stress! I feel flawed at how this is changing my biochemistry !Our bodies are so fascinating! Thank you for awareness 🙏

[Objective-web]

Amazing video, good job man!! Keep them coming

[Megaghost_]

I'm glad to have found this channel today. Subscribed!

[stevengill]

Psychoplastogen is such a great word! It'll be great if these compounds aid stroke and other traumatic brain damage...
According to that chart, psilocin should be less active as a plastogen since it's 4 - substituted...is it?(I think the OH is an exception)
Very cool, thanks again!

[petrektek]

Thanks for analysing DMT using science! Tanks god people like you exist!!

[robert.baindourov]

what about nndmt? does it potentially have long term brain changes?

[MrTrda]

Everybody talks about this being a potential for depression, PTSD, etc - but what about people without these afflictions? How can it be beneficial for healthy minded people?

[Leojuutilainen]

Id argue that ergolines are a more interesting addition to the human nervous system since AFAIK we dont have them (or something completely like it) in the brain. Also i think its right that for people who don't need intense problemsolving a low dose of something gaba-genic is probably more optimal that most peoples homeøstasis.

[enosanderson]

Why are some people not affected when they ingest Ayahuasca (DMT)? I know of a person who ingested increasing amounts of Ayahuasca over a 7 day period and the only effect was vomiting for each of the four sessions.

[lalaraeray]

So i used 5meo to come off of methadone. Very small amounts results in zero withdrawal for hours i believe it has something to do with all of this

[orangestoneface]

ssri make new brein cells grow but slowly so it takes months years l read, but other plasti whatev waork in a day .

[Dingbobber]

The answer is no, because most cases of depression and anxiety are caused because of damage to the gut