The Immune System Overview and Tutorial - Innate and Adaptive

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Hey everyone, this is a tutorial on the immune system which covers both the innate and acquired immune system.

Innate Immune System
1. PRRs located on neutrophils, mast, macrophage, dendridic recognize PAMP
2. Release of cytokines especially IL-1 and TNFa which act on
post-cappiliary venule endothelial cells
3. This leads to adhesion molecules, vasodilation and exudate
4. Adhesion molecules: "chemotaxins" IL-8, C5a, LTB4, cause rolling
of leukocytes on endothelial cells, adhesion, and migration
to pathogen
5. Tissue damage releases eicosanoids: prostaglandins PGI2, PGE2 (vasodilation)
and leukotriene LTB4
6. Opsonins created from complement cascade: C3b
7. Cytokines stimulate synthesis of vasodilator nitric oxide, increasing vascular
permeability.

For the acquired immune system, I go over how antigen presenting cells work in combination with T lymphocytes helper and T lymphocyte cytotoxic cells.

Some of my other websites:

[lanebreakerRBH]

you literally just saved my life!! best overview on youtube thats actually in detail. plus, your voice is soooo nice

[Robertmacdonald]

thank you- great video! Not patronizing in the least like a lot of these type of videos and not painfully slow or so fast moving that note taking is impossible! Much appreciate!

[lettamego]

Easy way to follow... with coloring things in as you go.... I'm finally learning.
Thank you.

[Baeu]

OMG, thank you, you explained this better in 14 mins than my lecturer did over 4 lessons.

[Elena-gbgg]

Honestly congratulations!.... I study medicine in Italy and I've never unsterdood so well immune system as in this video!

[fundip]

Watched these a while back simply did not know enough to appreciate how well done this is. very nice job and to do it in 15min wow.

[dokkiri]

Wow great graphics. If enough people like you work together to revolutionize medical education, we can learn more information, learn it faster and with far less pain and most importantly retain it. Once again. Good job and keep it up.

[itschillyoutside]

Thank you so much for the video! It really helps to put everything into perspective, I was having a really hard time putting all of the branches of the immune system together, how they all happen at the same time. This is a life saver!

[tndoma]

Excellent! Thank you so much - this is one of the best presentations on the immune system I've ever seen.

[VisualLearnerStudios]

Thanks for pointing this out. Yes, you are right, the Th2 cells cooperate with and activate B cells to proliferate and give rise eventually to memory B cells and plasma cells. I will make a note of this on the video.

[OmoItsekiri]

I love you man; that's from the heart

[acaughey]

Should be mentioned here that MHC-1 is expressed on all nucleated host cells. These cells present antigen from intracellular infection to the Cytotoxic T cells, and activate them, and apoptotic factors are pumped through a synapse with the infected cell. This pathway is much more common than the one shown in the video

[doughouge]

Very good general overview of the immune system.

[ShelleyDodt]

Great video!Puts everything into sharp focus. If anyone still has a problem there is a book by Lauren Sompayrac called How the Immune System Works that also explains things pretty good. Especially after seeing this if you need more detail. Thanks! You did a fabulous job!

[rajatubc]

Great video....a lot of effort put in. Great summary....quicker to learn. Thanks

[mysastyo]

thank you sooo much, i'm not using english as my daily language, so its very difficult for me to understand the textbooks. watching this video can wipe the fog in my mind. i start to understand imunology. :D

[hyperealityx]

Great video, we are doing this in our med course now. Very nice diagram. I think you meant IL-12 which differentiats Th-0 to Th-1 cells and T cells don't form B-cells or memory B-cells they release IL-3, IL-4 to cause them to become B-cells because they are 2 different lines. Good work, I really liked the video.

[ilearn]

Thank you for putting this together! This video is THE perquisite for watching Cells at Work😂

[robcooper]

Thanks for taking the time to put this together. You've done a great job!

[dsaf]

I am also wondering if you could put up a link to the diagram? I found it very helpful!!