Immunology - Antibody (BCR) and TCR Diversity

Understand how BCR (antibody) and TCR diversity is generated through gene rearrangement, junctional diversity, and somatic hypermutation in this educational immunology video. Essential for mastering adaptive immunity, this video breaks down the molecular mechanisms that ensure immune specificity and antigen recognition.

Describes how genes that make light and heavy chains can be randomly assorted to produce a unique type of antibody and so wil bind to a specific antigen~

📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓
👆No cap, these practice questions will make you a pro!

Support me:

Instagram:

Twitter:

[armandohasudungan]

📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓

[trustnoone]

at 3:06 you mention differentiation of Naive T cells into cytotoxic T cells or helper cells, the switch from double positive cells (CD4+CD8+) to single positive cells (CD4+CD8- or CD4-CD8+) occurs in the thymus, not the lymph nodes

[armandohasudungan]

I will on friday! sorry i keep forgetting to upload it.

[candyswift]

A great channel to share about antibody engineering! Thank for keeping it updated.

[holliday]

Your videos are very helpful.  I did notice that you have drawn a single (light or heavy) chain binding to a antigen and not both.  The variable region of a light chain and a heavy chain together recognize an antigen.  Not just one or the other.

[gracesassana]

I think there is a mistake in the video. T cell differentiation happens during positive and negative selection in the thymus and then differentiated T helper and cytotoxic T cells move into the lymph nodes. In your video, you had differentiation happening when the naive T cells entered the lymph node. That is incorrect.

[jennyshavarska]

Man you are great! I was totally bored with immunology before i found your lectures

[NRRJMA]

You have no idea how many med student u saved! Thank you so much for your effort

[gigimatz]

YOU MAKE ME ENJOY IMMUNOLOGY! THANK YOU FOR YOUR VERY SIMPLIFIED VIDEOS. I APPRECIATE ALL OF THEM FOR HELPING ME UNDERSTAND!

[luisperdigones]

Ive think antygens bind with antibodies between both the heavy and the light chain, "touching" all 6 CDR regiones, 3 in each chain. In 8:30 you make it seem as each antibody can bind with four antygens a once (it can only bind with two)

[porcupinehead]

very helpful, especially because you can talk at a regular pace but don't have to wait for your hand to draw the diagrams.

[aspektn.]

Great video. Seen once, shall be seen again.

[zeidyyy]

you are truly a life saver!! Thank you so so much for these extremely helpful videos.

[atsedebirhanu]

Thank you for making the videos, are very helpful nd clear

[xxdaantjexx]

You will never ever have to say sorry for that! I think you have saved so many peoples butt by uploading this video's :)

[ivetamosesyan]

You are doing a great job👍👍 God bless you❤❤

[m.pastrana]

@Mohmmed Al-Dosary CD3 receptor is part of the T-cell receptor complex (T-Cell + CD3^2 + ζ-chain), These proteins help the TCR to bind to the plasma membrane and communicate with the interior of the cell. CD3 and ζ-chain are to the T-cell what  alpha and beta Ib are to B-cell receptor. 

[tonioliver]

Hi

I'm a teacher of Clinic Diagnostic Analysis in Mallorca, Spain. I have to teach Immunology and I am using your videos, the linearity of the argumentation helps a lot in dealing with the inmune mess. Thanks a lot for your work!

Any chance of having the image of this one uploaded?

[aishwaryasutar]

The best video i saw uptil now, the presentation was the best👍

[cristianvargas]

You should add combinatorial diversity and junctional diversity as part of diversification of BCRs an TCRs, apart from that video was pretty good :)