30. Immunology 1 – Diversity, Specificity, & B cells

MIT 7.016 Introductory Biology, Fall 2018
Instructor: Adam Martin

Professor Martin introduces the topic of immunity, defined as resistance to disease based on prior exposure. Beginning with vaccines as an example, he gives an overview of the immune system, followed by its properties of specificity, diversity, and memory.

License: Creative Commons BY-NC-SA

[eurusgreenway]

you literally can't present the same content in a better way. Excellent lecture and excellent lecturer!

[ShakhawatHossainShovon]

Thank you so much sir and congratulation as well.
You have marked your footmark in the history.
Students even after a century will learn from your classes.

[garetcrossman]

Well done Rodney for getting away from Del Boy.

[cwagner]

Excellent lecture. Very clear. Thank you.

[ricobelled]

Cardi B farts and hundreds of million views, but this FREE gem of information has 30k views. The world we live in....

[Funwithmecam]

I'm about to be late but I'm here. Such a great literature here

[okpolihenry]

Antigen does not always activates the immune system buh immunogen does

[anthonybove]

Comprehensive and excellent presentation.

[phoebewang]

Very helpful and inspiring, thank you.

[alicekao]

I have a question. In the example of herceptin, why not we just use the antibody totally generated from human (including the CDR), but instead, using the engineering to combine mouse CDR region with human to do immunotherapy? Thanks.

[felipebressan]

Is it possible to cancer treatment kill memory B cells? Like, our adaptive response will get damaged and our vaccines may turn ineffective...

[gogemusicimprov]

41:45 HOW would a recombined allele suppress the recombination on the other allele? If it is not known yet with certainty, better not state it with certainty.

[chandrasekharChebiyyam]

I am super excited about the combination of the facts that AlphaFold has solved protein folding problem and there exists antibody therapy. Bring it on antibiotic resistant drugs!

[dariomics]

The B in B Cell come from Bursa of Fabricius which, funny enough, humans don’t have as it was found in birds 😂

[zack_]

Both T cell and B cell originate from bone marrow. Then B cells migrate to, but not produced by, the thymus.

[khgnew]

great professor. I am just not clear of the gene rearranging in B cell diversity. can anyone make it simpler?

[nibussss]

B cell secretes? Sometimes..lots of guys recognized
T cell nmscretes..
Recognizes peptides....

[ankeu.a.wallace]

Excellent lecture & Thank you!!!
👍😇🇺🇸💧💦🌊😘💖

[civilape]

To the memory aspect of it, does the time lapse between the 1st and 2nd response a factor into the efficacy of the secondary response, and the tertiary, and so on?? i.e. if you're exposed to the same antigen within days/weeks/months, vs. years vs. decades is the secondary response always as efficacious?

[onciblu]

"The "B" comes from the bone"

I thought it came from the bursa