liver

Connective tissue from the hilus of liver extends between the liver lobes as interlobular septa. Interlobular septa contain interlobular branches of the portal vein, hepatic artery and bile duct, which are collectively considered as portal areas or portal triads. Arterial and venous blood mixes in hepatic sinusoids and flows toward the centre of hepatic lobule, where is a central vein. Radiating from each central vein toward the lobule periphery are plates of hepatic cells (hepatocytes). Located between hepatic plates are blood channels, hepatic sinusoids. Hepatic sinusoids are lined by fenestrated endothelial cells with discontinuous basal lamina. Hepatocytes secrete bile into bile canaliculi located between individual hepatocytes. The canaliculi converge at the periphery of the liver lobule and empty into short canals of Herring, that merge in the portal area with bile ductules. These ductules are lined by simple cuboidal or columnar epithelium.

Stained: Mallory trichrome (connective tissue is blue, muscle tissue is red, erythrocytes are yellow)
Author: Mgr. Tereza Blassová, Ph.D.
Scaning of the specimen: Mgr. Yaroslav Kolinko, Ph.D.