ANCA: The Vasculitis Antibodies

ANCA or Anti-Neutrophil Cytoplasmic Antibodies confuse even the most seasoned doc! Closely associated with vasculitis, they can be buried in the long list of antibodies checked when getting a rheumatology consult and are often overlooked. What do they mean? When do we use them? And what about an "atypical ANCA?" UGH!! We aim to clear it all up in today's video!

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The guide you need to tell your doc your story -and get answers once and for all!

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⏱Time Stamps:
0:00 Intro
0:58 What is ANCA?
2:33 Different types of ANCA
3:42 Vasculitis 101
6:51 The ANCA associated vasculitides
7:53 How to interpret your +ANCA result
11:18 What you need to fully interpret your result
11:49 Does a +ANCA mean you have Vasculitis?
13:06 Making a good symptom list: The Productive Rheumatology Appointment Guide
14:18 What about the "atypical ANCA" result?

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👩🏻‍⚕️ About me:
Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor.

We discuss all things Rheumatology, Immunology, Diet & Movement & Mental Health & Wellness because we believe IT IS ALL CONNECTED!

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.**

[JPinthe]

Doc is still trying to get me figured out. Treating for PMR with prednisone. I had 6 months of excruciating pain in shoulders, biceps and hips before I could get into the rheumatologist. Speckled pattern and titer of 1280. I do have low numbers of centemeres and a low positive NXP 2 antibody. No real crest symptoms, but some trouble swallowing and dx with globus sensation last year. Now, more of finger, toe and wrist pain. The CT of my lungs showed no fibrosis, but pulmonary hypertension and accidentally found clogged coronary issues in my heart....hope to get that build up corrected sooner than later. Your video are very informative 🙂. Thanks.

[TarynCelestine]

Thank you so much for the information! I was just recently diagnosed with the P -ANCA fluorescent and leukocytosis and IGA mediated ❤

[jalen]

I tested positive for anca, but negative for the specific test. That was maybe 8 months ago, now I’m negative for anca and negative for both specific test as well. That was confusing to me. But I’m glad their negative.

[jackg.]

I want to say thank you for these videos. They are very helpful because I can watch them multiple times, rewind, and take notes in a way that you can't really do in the moment in a doctor's office.

I'm wondering if you've ever made a video about relapsing polychondritis in particular or about rheumatic conditions in general where there is no single associated blood test?

[laurendenson]

Could you cover ANCA NEGATIVE vasculitis?

[daniellerandall]

Great video really easy to understand. Thank you 😊

[patriciap.]

Very illuminating segment, Doctor. Thanks ☺️

[anitadai]

Your videos are very informative, Thank you !

[lretba]

Thank you very much for explaining this. Very much appreciated.

[julianfalciola]

What type of imaging can be done to identify and help in confirming a diagnosis of Vasculitis?

[captainhml]

I have Wegener’s Granulomatosis/GPA and Goodpasture’s Disease/Anti-GBM Disease. I am double positive.

[catalinadgallagher]

Thank u for a very clear explanation
Ive been in the doctor scared me

[teresahuerta]

My Daughter just tested positive for ANCA but they did not explain anything else but that she was positive for Anca she is getting a Cather and Drs are talking about a kidney transplant..
But watching your video I believe you really can help us.

[AubreeFusselman]

I have the atypical ANCA and I feel absolutely awful. I’m curious to see what comes of it.

[elinordrake]

This was very interesting! Thank you! Do you have any video's that address what it might mean if you are ANCA positive but ANA negative? I sort of have this idea that ANA is supposed to be positive with most Rheumatological stuff. Thank you!

[xdreamscometruex]

I went to my GP last year with a swollen finger did bloods got a positive ANCA the results was query vasculitis, but because I have IBD the GP looked online and said as I thought that's positive with IBD no further investigation fast forward 18 months said finger is completely deformed and the next finger is now swollen and inflamed so finally got an urgent referral to rheumatology. Not sure if vasculitis can cause this also got possible raynaud's but not been diagnosed.

[nsas]

Thank you very much. You are great. I love you.

[hannaleigh]

Hello,
Can you please answer a question for me?
I year ago I had a positive ANCA test with atypical perinuclear staining with no antibodies detected. I was very sick with the same symptoms I am experiencing presently.
Now, 1 year later I had a positive ANCA test with atypical perinuclear staining once again, but this time I tested positive for MPO antibodies.
In some cases do the MPO antibodies take some time to show up on a blood test? In other words, early in the disease is it possible to not have developed the MPO antibodies.
Also, it important to mention that both tests were run twice to confirm the results were accurate. Both times I had the ANCA test and also a separate test to confirm that the antibodies were present.
I would be very grateful if you could help me understand why the antibodies took a year to develop.
Thank you in advance

[Lulu-mnsc]

I have Vasculitis of the kidney Anca. When I relapse I have to receive infusions. Please explain.

[Sumer]

My ANA was negative
But they noted: cytoplasmic staining seen


Is this something I should worry about and see a rheumatologist?