ANCA Associated Vasculitis (Anti-Neutrophil Cytoplasmic Antibody) - Causes, Pathophysiology, Types

"Small Vessel Vasculitis Vasculitis is inflammation of the blood vessels resulting in damaged vessels leading to potential complication such as tissue ischaemia from lumen narrowing or from thromboembolic events from platelet consumption during vessel repair. Primary vasculitides are classified into the size of the blood vessels affected; large vessel, medium vessel and small vessel vasculitis. The small vessel vasculitis can be further divided into ANCA associated vasculitis (AAVs) and immune complex mediated vasculitis.

ANCA associated vasculitis is so called this because in the person's blood there is presence of ANCA which is an abbreviated to antineutrophil cytoplasmic antibody. AAVs usually tends to affect small and medium sized arteries. There are three main types of ANCA
- Microscopic polyangiitis
- Granulomatosis with polyangiitis
- Eosinophilic granulomatosis with polyangiitis

The pathophysiology of AAV involve presence of ANCA and also granulomatosis.
ANCA target certain proteins in the cytoplasmic granules of neutrophils and monocytes. The neutrophil for example contains enzymes myeloperoxidase and proteinase 3 in granules. What it thought to happen is that during inflammation cytokines such as TNFa and IL1 stimulates the translocation of proteinase 3 and myeloperixoidase to the cell membrane allowing these enzymes to be exposed."

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[armandohasudungan]

🎥 DON'T JUST WATCH, LEARN ACTIVELY! TRY THE QUIZ! 🤓

[Vysair]

This channel is way too underrated and underpaid. Not only the quality of the video kept improving, this channel still continues upload a new video despite having such low view count. Thank you for your effort.

[murtazashaykh]

Diagnosed "Necrotising glomerular nephritis" ANCA associated. Really helping me to understand underlying cause through your video...

[LEVI]

Your drawings and handwriting are extremely aesthetically pleasing! I wish i could draw like that!

[chemoman]

This is amazing work. You are amazingly talented, both with your descriptions and your drawings! You should write a textbook - thank you so much for helping me with understanding this topic.

[theoraypa]

It's so cool! Man I need more videos on small topics, which are clinically so important.

[theoraypa]

I like the new way of yours like upgrading yourself with more computerized help and detailing with your diagramming the studies..!! 👋🏻🤩👏🏻 it's worth praise

[splinky]

I actually suffer from c ANCA baffled a lot of doctors just to diagnose it. I’ll be ok, but it was a pretty close thing

[kristacrowder]

Thank you for the thorough presentations about vasculitis. I am wondering why polymyalgia rheumatica was not discussed in the small vessel category.

[xaaboopinkly]

Huge thanks sir! Your videos are always the best!

[titionthewall]

Just today I have a pediatric patient with suspected granulomatosis with polyangiitis. Your video helps a lot in further understanding the disease. Thanks a lot!

Btw orang Indonesia kah, dok?

[ahmadaljazeeri]

In Which year do medical students study this material?
Great channel and amazing work!

[mohamedmohamed-nptb]

Thank you very much ! Well structred and well presented

[jeanetteraichel]

Would Zika infection cause vasculitis?

[chinmaypatwardhan]

Hey can you please re-upload the brain physiology video. Also thanks to your Kidney videos i got 350/ 360 in my test

[SourcingtoSales]

Hey man, great quality video!! Can I ask for some advice? I am starting a PhD vlog channel and am wondering if you have any tips? Thanks a million man!

[ramonab]

Does ANCA vasculitis cause reactive amyloidosis? I have diagnosis of severe autoimmune Neutropenia and Aa amyloidosis. I have anca antibodies but no diagnosis of certain vasculitis

[thefenerbahcesk]

Why do the B cells produce antibodies against the bodies own enzymes?

[saumyas]

unable to find the image in your store, help?

[ncooper]

What is that large kidney shaped thing supposed to represent?