Alzheimer's, Sleep Disturbance, and Brain Health

Studies present an association between APOE4 and sleep disturbance. Additionally APOE4 is linked to sleep disturbance before the onset of Alzheimer's symptoms. In ‘The Sleeping Brain’ article (see below) the authors suggest that sleep disturbance causes reduced removal of the waste products from the brain, leading to the accumulation of beta amyloids - which in turn is observed in Alzheimer's disease. Additionally, it is thought that APOE directly leads to beta amyloid metabolism disturbance. And, finally, it is thought that stress-related proteolytic cleavage of APOE4 leads to accumulation of tau proteins. Let's review the evidence.

DrBeen: Medical Education Online

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URL list from Monday, Feb. 20 2023

The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC

Sleep well — and reduce your risk of dementia and death - Harvard Health

APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Text

N3 Phase of Sleep.

Understanding Delta Brain Waves And Sleep

N3: Slow Wave Sleep | Sleepopolis

Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagram

A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagram

Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagram

Frontiers | Perivascular Spaces, Glymphatic System and MR

Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink

Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System

Neuroglia Lab : Glymphatics and virchow-robin space

Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology

Aquaporin-4 - Wikipedia

Astrocyte - Wikipedia

Neurocytology-Astrocytes

Blood-brain barrier | RIT

The Blood-Brain Barrier | Morphology of Nervous System

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier | Fluids and Barriers of the CNS | Full Text

The glymphatic systems in the brain and the eye export fluid and... | Download Scientific Diagram

Cervical Node Mets fron Occult Primary

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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

[jayson]

Thank you for the info. Could you look into heart failure rising cases and prevention? Keep ul the good works Dr Been

[harvinderubhi]

AD is not age related, the subjects you describe are lifestyle issues ..the cumulative effects of the poor lifestyles sadly shows up later in age. Important therefore to stress importance of lifestyle, including sleep, exercise, NIR exposure, diet, stress, environment, etc.

[Aetherfield]

Sleep hygiene aside, which drugs or supplements are safest to insure productive restorative sleep? … Cannabis, Trazadone, Ambian, Anti-histamines, large doses of Melatonin, …. Unfortunately herbal supplements do little for me and I have been on Trazadone and these others for 40+ years. Perhaps it is best to rotate them?