Dr. Peter Attia: Supplements for Longevity & Their Efficacy

In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.

We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.

Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.

Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan.

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*Dr. Peter Attia*

*Timestamps*
00:00:00 Dr. Peter Attia, NAD Pathway
00:02:31 Sponsors: LMNT, Levels & Eight Sleep
00:06:38 Categories of Longevity Approaches
00:17:22 Peter’s Supplements; Rapamycin & Research Data
00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho
00:30:35 Sponsor: AG1
00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan
00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan
00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol
00:53:31 Perform with Dr. Andy Galpin Podcast
00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health
01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes
01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program
01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance
01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits
01:30:38 Longevity, NR & NMN Supplementation, Inflammation
01:41:00 Rapamycin & Immune Function
01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor
01:55:24 Radiation & Cancer Risk
01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline
02:07:12 Tool: Exercise Timing & Energy Levels
02:11:22 Peter’s Supplements
02:18:46 Andrew’s Supplements
02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy
02:26:52 NAD Pathway Supplementation for Longevity?
02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter

[hubermanlab]

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Thank you for your interest in science! -- Andrew

[cirorobertocaramia]

My grandmother, 105 years old, grew up in the countryside working physically every day, and with natural food mainly from self-cultivation and breeding, genetically in a centenarian family (her father died at 94, her last sister died at 99), self-conviction of being strong ( still affirms it), practical approach to life (despite the daughter of an alcoholic mother), no caloric restrictions but still current ability to self-regulate with regards to food intake (however, excellent appetite), lover of life, still sleeps many hours a day, grateful to God and his will. I believe that here are all the natural secrets of longevity

[evolved.health]

This episode points out the very clear difference between a clinician who cares about actual outcomes and a researcher who just looks at papers. Always appreciate Attia's scientific and clinical rigour.

[SILERSECT-kctq]

Can't recommend Dr. Peter Atia's book Oultive enough. So much good info and relatability that it really helped me with my health goals. Down 160 lbs in less than 3 yrs thanks to these 2 amazing people and I cant thank them enough!!

[Mike_Virata]

When you see these two names together, you know it's going to be a good episode!

[minecrafthacker]

I've never seen Dr Peter like this it's as if he's sick of the mis information, I appreciate the no nonsense approach.

[jordanschwartz]

I am a big fan of Peter Attia (and Huberman!). I've followed him since his first Ted talk over ten years ago. I observe that Peter gets uncomfortable (and rightfully so) when discussing supplements. Peter hesitates to discuss them because people take it as advice and automatically consume what he consumes. He acts like he has to jog his memory to recall what he takes, yet he takes them daily. I think it was his hesitancy and strong principles to list them out; to me, that is just another indicator of how responsible he is as a doctor. He even went as far as clarifying how insignificant supplements are compared to other things such as sleep, exercise, diet, etc. I really appreciate Peter for that. On the other hand, Huberman freely talks about what works for him and I also appreciate that. We are curious and we want to know what the experts know and thanks to him, we know a lot.

[xix]

Hi Dr. H, thanks for the informative episode and wise words about supplements. As a medical doctor myself, I would appreciate if you did an episode on kidney health. Many supplements and OTC medications can place stress and cause permanent damage on the kidneys, and the symptoms are not apparent until there is a 30-50% decline in kidney function. I feel the general public should be aware of this to make wise decisions about taking supplements. Thanks for what you do.

[anthonycacharron]

Am I the only one to feel like this is a battle of Titans of science? Exceptional episode!

[HeatherQ]

I could watch this conversation a billion times and never get bored or disinterested. This is a beautiful way to use the internet! 😊

[sunflowersadie]

I love that these doctors/scientists are experimenting on themselves for the good of all of us. Thank you

[adamhowden]

When Peter Attia and Huberman get together, I find Peter uses a lot of jargon that makes it a tough listen. 🤘🏻❤

[tinabrotbackgeraet]

My friend had a small stroke and wasn't feeling very good. 6 weeks after her stroke, her doctor recommended NAD IV and it made a world of difference for her. Her concentration got better, and she had more energy. I get Take it for energy, and it takes care of my brain fog.

[yuwonowibowo]

Would be lovely if you could also invite David Sinclair to the argument. I am no die hard fan of him either but would be perfect hearing from him.

[EmilySmith-bvwb]

I was really looking forward to this episode and I enjoyed it, but I found Dr Attia to be difficult to listen to at times. His delivery was quite abrupt and sounded a bit dismissive of Dr Huberman. Conversation didn’t flow very well. It was just off putting to me as it came across as a bit disrespectful. I respect Dr Attia’s knowledge but I think his delivery wasn’t great.

Very informative podcast though, thanks Dr Huberman!

Podcast suggestion: I’d love another episode on skin, touching on dermatitis and eczema.

Thank you! 🙏🏼

[angeladavies]

27km of hiking today and 1.5 hrs in gym; listened to this podcast + Peter Attia The Drive & The Proof with Simon Hill. Excellent, inspiring, educational. Don't be in an overfed state, RT, sleep, move, don't be miserable angry. My Pa said to me decades ago exercise wasn't practical, he smoked, died in his 70s, My other Grandpa was a paraplegic. Ma had osteoporosis, broke her hip, smoker died 70s, Other grandma breastcancer died 52. Glad, so lucky I am able to be educated.👩‍🏫

[OurFamilyInMotion]

Agree with Peter's comments re: nutrition, exercise, sleep, and mental health being the main pillars of optimal health with supplements being a secondary or tertiary concern. I would add avoiding alcohol as one of the main pillars.

[oppmand]

Love the Huberman Lab podcasts, and also Dr. Attia's podcasts. In this podcast, however, Dr. Attia mostly speaks in acronyms and language that require a medical doctor or PHD training in the subject matter. It would be appreciated is if the information could be expressed so that an audience composed of the general population could understand.

[laneythelame]

Dr Attia is always such a great guest, thank you Andrew!

[bobbobby]

40 year old male. I take 1g NMN daily. Gives me a boost of energy for sure!