How fake flavour molecules trick your tongue

Artificial sweetener works by binding to your sweetness receptors but they provide no calories. What effect does that have on the sweetness receptors in your gut and can your other taste senses be tricked in the same way: sour, butter, umami (savory) and salt?

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[SteveMould]

You can discuss this video over on REDDIT if you want: stvmld.com/jrwepagi
Bitrex really sticks around in your mouth. I regret filming that bit for real.
You can support me on Patreon to get access to the bonus video here: stvmld.com/fbku3aj2

[luminoustedium]

This is the LockPickingPlant, and what I have for you today is a sweet taste receptor from a mammal. Usually you need sugar to open this, but there is an almost unforgivable amount of sloppiness in this design. I'm going to show you that not only can it be opened with a low-cost protein based attack, but how it's so much easier and more effective than doing it with the proper glucose.

[integza]

I was not mentally prepared to see that shot of you pooping in the woods Steve

[unvergebeneid]

Pooping out seeds right next to a huge established tree is a total dick move. Please be considerate and poop out in the open where the new plants can get plenty of light. That's the deal!

[spookstory]

Hi Steve, I work on taste receptors as part of my PhD! And you're right about the brazzein binding to sweet taste receptors, but it only binds to one half of the complex, T1R3. Curiously the same part that is present in umami complexes, despite not causing an umami taste!

[famitory]

mint also works like capsaicin, activating the TRPM8 receptor which is intended to trip around 20-26 Celsius to detect cool, but not cold sensation.

[PetrHosek]

This reminded me of a hypothesis I figured out a couple days ago considering the typical "kindergarten puking chain reaction" – it may be beneficial for animals living in groups that they all start vomiting (or at least become more susceptible to it) once one of them shows signs of poisoning just in case more of them ate the poison, maybe a little while after the first puking individual.

[joshuaewalker]

10:44

Steve: "Gorillas have evolved."
*Cuts to a video of a gorilla picking its nose*

[FraktalPriest]

Steve Mould mentions the words "Benign Masochism", and everything in my life fell instantly into place.

[sepulcrumsumus]

So, that time I had a huge piece of cake and decided to have coke zero to compensate...I was actually introducing a Trojan Horse to myself.

[alexsparks]

You’re exactly what I wish my science teachers could have been like. Engaging, funny, interesting. Your points are often things that would otherwise be difficult to grasp but with your explanations become an interesting topic. Keep up the great work!

[bluebaconjake]

10:45 i bet that gorilla is stimulating their proton receptors

[osyazthegreat]

"Gorillas have evolved"
Proceeds to show clip of gorilla ferociously eating the boogers from its nose

[caleblimb]

Aspartame actually has the same caloric density as sugar (4 Calories per gram). The difference is that it binds much more strongly to the taste receptors and so less of it is needed.

[RadioactiveLobster]

Benign Masochism would be a great band name.

[nobodynemoq]

I love your sense of humour. It makes your videos much more entertaining, yet still very comprehensive.
And... OH MY GOD! I've never thought how brussels sprouts grow! It's hilarious!!! ♥️

[Panj]

8:19 What is a System Aert? :P

Pointing out typos makes me feel like a big man.

[davideisner]

Your description of hydronium was good up to the point you compared it to the Na+ • 6H2O hydration shell. H3O+ is covalently bonded and also has a shell of H2O molecules that are not covalently bonded to it. It is not the same as just H+ with a hydration shell. It is still written H+ as a shorthand, but was originally written that way because it was thought to exist stably in that form, which is now known to not be the case.

[sullychow]

"Gorillas have evolved their sense of taste". Shows a mummy gorilla eating her bogies while holding her baby. Lovely.

[msachin]

Chillis: create a specialized chemical over millions of years to dissuade mammals from eating them

Humans: *Now This is some Gourmet Shit right here*