What is Treatment Resistant Depression? #shorts

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Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.

[areeyapengwong]

I was diagnosed with Depression as well as ADHD many years ago. I was prescribed Venlafaxine for the D and Methylphenidate for the ADHD.
The Venlafaxine did nothing for me. I was introduced to psychedelics mushroom from *mycotask* for treatments of my depression.
I tried a mild/medium dose of psilocybin, it was for recreational trailer purpose but I noticed for a few weeks after the experience, that I felt overall better mentally
speaking, I felt happier, more in control of my feelings, social anxiety was gone etc. All from 1 experience!

[cherylthompson]

I have major depressive disorder. Difficult to treat. Im still here ❤

[queenchels]

I could never get to 6 weeks because the antidepressants would make me so physically ill(nausea, vomiting, shaking and fainting) that it was dangerous for me to continue antidepressants. This happened with 3 different prescriptions. The medication can ABSOLUTELY fail without taking it for 6 weeks.

[burytheseoldghostsdwn_]

I've been in therapy and on meds since I was 15. I'm 35 now. I grew up with some special needs, mostly just mild learning disabilities. Over the years I have been on every medication under the sun and never got anywhere. Everyone treated me as just another really depressed and anxious person. A few years ago I found out that my whole life I'm actually a higher functioning autistic, which explains why I've never gotten much relief through medication. If you've been struggling with this all of your life I encourage you to find a psychologist and get tested. Unfortunately many psychs and therapist aren't trained to spot autism. I even went for TMS treatment recently, the full 6 weeks and only saw a very slight benefit from it. For many autistics with treatment resistant depression it comes down to more life skills and training and figuring out how to cope with the bad depression days than actually getting rid of it completely, since autism itself can mimic many of the signs of depression emotionally wise.

[GCATLiving]

What about ones where all of the side effects were having a bigger impact on your life than your actual depression?

I've been through several medications where technically my depression went away, but the side effects of the meds were so bad I ended up right back where I started because they made me miserable.

[olafelsberry]

Dr. Marks thank you for educating the public about psychiatry.

[santiagocruz]

Yeah, but the issue is the added desperation of taking positive steps that aren't working with depression. 2 months without reconsidering dosage without reconsideration. I would consider that failure of care.

[Kayette]

The waiting period for relief is excruciating with no real suggestions to get feeling better fast, and the eventual failure of these antidepressants for me nearly drove me to unalive myself. Ketamine and acupuncture are going to be my last stop gap between being above room temperature and being in a body bag. I do not have any more 'wait and see' energy nor do I have the abundance of money to throw away to antidepressants that will eventually fail. I'm fed up despite trying so hard.

[JohnMark-bxks]

gosh 6 weeks before it take effect, my goodness thats long time of hopelessness, wanting to die, anhedonia, hypersomia and even physical pain, low energy

[strangeduckling]

US. Only 2? Gotta pump those numbers up 💪
But in all seriousness, I think at least a couple of mine weren't at the minimum effective dose, but it's like my psychiatrists were afraid to up me! I'm a fairly petite female, so I guess maybe that's why they were hesitant, but I have a naturally high tolerance against a lot of drugs for some reason (let's hope I never need pain meds smh).
The only drug that has ever worked for me so far (whether for depression OR anxiety) was Lexapro, and stg it only worked for two weeks 🙃
Due to the sheer frustration of it all I haven't been on anything in over a year, and tbh it's nice not having to think about it :)

[breezystl]

Damn, I must have the most treatment resistant depression EVER. Only 2 drug trials?? I've tried pretty much every ssri and snri known to man 😂 Someone send me a new brain please.

[michelekurlan]

I tried 3, approx 30 years ago. Mood improved but developed migraines needless to say I stopped but the migraines never completely stopped.

[Albinojackrussel]

Can you define what "don't feel better" means. Does it include people who feel better initially, but then it stops working again, or is it specifically people who never see a mode increase?

[mikeythedistasteful]

Finding the right medication is the most frustrating part of all of this. Then there’s finding the optimal dose, after almost a year of trial and error I’m finally where I need to be

[csc]

Had severe side effects on 5 different kinds. Totally against them.

[kennethokeefebrake]

Hi Dr Marks,
I didn't have treatment resistant depression, I had a misdiagnosis which I detected with you help.
Psychoactive drugs did mess me up but I recovered, thanks to Dr Daniel Amen. I do the things one must do for mental and physical health. The only med I take is 37.5 mg of Effexor 6 times per week for chronic pain management, thanks to Dr Andrew Gross. It works!!!
❤️
thanks for this educational content
Otherwise ZERO MEDS.

[katiehemming]

Maybe add a mood stabilizer then? I’m on a antidepressant and a mood stabilizer. That’s what worked for me. I had to go on a mood stabilizer for my psychosis episode, after some tweaking I’m back to normal. I’m a bit afraid of going off of my mood stabilizer because I worry about my psychotic symptoms coming back, however I am not depressed anymore. I don’t like the unpleasant side effects from it though.

[amaliasuvac]

Don't you think that depression or any other mental illness shoud be treated by the cause, not by the symptoms? I think that you can treat the symptoms with medication but that wouldn't cure the person from depression. But I think that if you work on the cause of the symptoms and come to a point of poise with the therapy sessions, it would be the best solution. What do you think about that?

[amygerstle]

And what do you do when your psychiatrist won't listen to you about your depression and keeps you on the same thing for years and won't change it just wants to add yet another pill. So frustrating. Makes me feel like a guinea pig.

[mitchellrose]

Very helpful. Except the use of second person malady descriptions. It seems to attach disorders on people's minds in a subconsciously influential way.