T cell memory | CD4 and CD8 T cell memory

T cell memory happens after T cell activation. This video covers what CD4 and CD8 T cells are and how they form memory responses. CD4 T cells are known as helper cells and aid other immune cells as they remove bacteria. CD4 T cells also activate B cells. Through B cell activation CD4 T cells are responsible for antibody creation (IgG, IgA, and IgE). CD8 T cells are also know as cytotoxic T cells and directly kill cancer cells and virus infected cells. T cell activation begins with expansion and then contraction. T cells that survive contraction are T memory cells and can create T cell clones for years.

Migration of Memory T cells
Defining memory T cells
CD4 T cell memory

[nelsondullugaulu]

Thank you for explaining this in a simple manner, I work for a Oncology product company and we have 2 Immuno-Oncolgy products work PD-1 and CTLA4 pathways...your video helped me gain further knowledge

[ogaana]

Absolutely my favorite cells and I am amazed at our complex biology 🐱✨our body is an incredible organic machine !!

[ellie]

OMG, you are so much better than my teacher!

[wladyslaw]

what a lovely presentation, beatifulle person also

[Noris]

Thanks for talking about T cells! Keep up the good job!!👏🏽👏🏽

[joeycan]

Great video once again, loved it !! Please keep them coming, and stay safe.

[celestialfix]

Thank you. Very interesting. The immune system is kind of amazing.

[whoami]

Thanks for making this video! All of them are interesting and clear! I do have an unrelated question, how does a natural killer cell work and can it be affected by cytokines?

[Conscious_Sea_Magic_Wave]

Thanks a lot! This is the best T cell video I've ever watched! What do CD4 and CD8 mean？It looks like that they are some receptors on the T cell surface.

[ilmendo]

Are also eosinophils related to plasma b Cell or t Cell ? Thank you again ❤❤❤

[dougpenhall]

Can you talk about how T-cell receptors are created and the difference between them and antibodies? There’s some talk about peptide vaccines.

“Peptide-based synthetic vaccines, also called epitope vaccines, are subunit vaccines made from peptides. The peptides mimic the epitopes of the antigen that triggers direct or potent immune responses.[1] Peptide vaccines can not only induce protection against infectious pathogens and non-infectious diseases but also be utilized as therapeutic cancer vaccines, where peptides from tumor-associated antigens are used to induce an effective anti-tumor T-cell response.”

[danimari]

I just want to say 1. you kinda look like Shakira hehe 2. this video was very helpful as a dental student struggling with immuno, thank you!!

[ilmendo]

I have a seronegative celiac disease that it seems to be refractory at this stage.
I have my hla dq2 positive ( hla dq2 and hla dq8 associated with celiac disease).
I thiught that i had and IgA deficiency but It seems that is not the case.
In this case, would you think that is cd4 failure or immature b Cell ?
Last year i had my latest gastroscopy and my cd3 counts were below the 25 counts.
How can you test for immature b Cell ?
Is It part of the Mhc 1 or 2 ?
IgA and IgG are produced my Mhc 2, IgE Is Mhc 1 or 2 ?

[dottyjyoung]

So, if a disease progresses faster than the T-cell expansion, does that contribute to negative outcomes or morbidity?

How does a high or low viral load affect immune response?

[jameswilliams]

This has been a challenging time, and I appreciate you so much Dr Alued, you have created a life that I thought was lost, thank you so much for curing my sister from genital HIV I am grateful

[kristadavis]

Do you think it is necessary for someone to get a Covid vaccine if they have recovered from Covid? Memory T cells are already there now, so what's the purpose of a vaccine? Also I am curious about reinfection with Covid. What does a second infection look like? Is it less severe because of established immunity? These are common concerns for many people. Thank you. You are an excellent teacher.

[angelfreedom]

To create antibodies, cd4 what do they need?
I have a seronegative celiac disease.
I had a total atrophy with no inflammatory markers.
I also developed atherosclerosis and ms.

[mballer]

What do you think of the doctor who is saying cd8 cells drop after covid vaccination and there has been something like a 20 times increase in endometrial cancers he is seeing since January?
Could this be possible?

[MATTETRUEFACT]

Informative..A Question. What is the normal T-cell and helper cell count, for "young" people in their early 50ties:). I took a full test from a laboratory, and it came back that i had a normal immune system..all levels were in the green Zone (set values) but id like to know if ia person still can improve and boost the immune system to levels like being mid 20ties age? I took the test beacause i am waiting for Novavax vaccine and have been doing so for over a year. Another question. Is it possible that having all the child diseases like smallpox, and all the other "happy" viruses that ruin the childhood for a period of time:). Can they lay as a foundation for some natural immune system boost against Covid? Some sort of natural T-Cell kick in system for viruses with similar structure like Corona viruses in general? Hope for an answer..thank you from Sweden.

[michaelchaff]

Am very late to this discussion but came across it as I was looking for an explanation in a case I have where CD4 count is .10 CD8 is .24 and CD3 is .66 (all 10*9/L). What I cant figure out is CD4 added to CD8 would only be .34 which makes CD3 194% of that. I thought Cd4 plus Cd8 should almost equal CD3. So, what then is expressing CD3 but is not a CD4 or CD4?