Immunology | T- Cell Development

Ninja Nerds!

Join Professor Zach Murphy for our lecture about the thymus gland and T-cell development. We go into detail on positive and negative selection, and the movement to secondary lymphatic organs. We hope you enjoy this lecture and be sure to support us below!

References:
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● lberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P . Molecular Biology of the Cell. New York, NY: Garland Science; 2002
● Murphy K, Weaver C. Janeway's Immunobiology. Garland Science; 2016
● Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. Lippincott Williams & Wilkins; 2012
● Levinson W. Review of Medical Microbiology and Immunology. Lange; 2012

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@NinjaNerdSci

#ninjanerd #TcellDevelopment #Immunology

[katerbrig]

There's a big difference between an expert and an expert who can teach. Thank you for being the latter.

[ahmedelhenawy]

This was more informative than a 2 hour university lecture from a phd that has written his own textbook on immunology.

[carolinerivera]

I have been teaching this stuff for close to 20 years and yours is the best explanation I have ever seen!

[Almogk]

This is how education should look like. Thank you!

[sayalidukare]

Plz make a whole series of an immunology leacture, it's very beneficial to us

[hamzenouh]

you guys are helping humanity. you deserve the highest award possible for education

[princessjazz]

GOD BLESS U MAN.... I dont know why we go to universities at this point when we learn more from Youtube than our Professors.

[xSEALsx]

Teaching cannot get any better than this. This is the best I’ve seen by far.

[chandlereyre]

Thank you for the video! I did want to add/ask one thing, however. Current medical student, and we were taught that the downregulation of CD4 or CD8 on the thymocyte is due to the interaction between TCRs and the MHC 1/2.

If the TCR (by chance) interacts with MHC1, then the corresponding CD8 will also interact alongside it, and CD4 is downregulated.
If the TCR on a thymocyte interacts with MHC2, then CD4 will persist, and CD8 is downregulated. I guess this differs from your explanation in that you imply the CD's are what determines this varability and choice. But I believe the chance originates from RAG recombiation to the TCR earlier on. Thank you for such a helpful video!

[elenasultan]

Good teacher. Shame that we can only see and learn from YouTube nowadays when the course has been paid thousands of pounds and no one there to teach, so I end up listening this guy here.

[amdgarcia]

Please please make more on the immune system 🙏🏽 your videos are very detailed and explained well for someone with no medical backgrounds. Mom has had auto immune disorder/RBCAPLASIA (acquired). And when we found out we were so lost and confused because her doctors would explain it in medical terms, we didn’t understand anything until we started searching and watching videos like yours. Truly appreciate you, I feel like I better understand her situation and feel confident explaining it to others as well

[humanitytribe]

Thank I spent hours trying to understand this in my text and you literally helped me completely understand it in a short period with zero confusion.

[MK-ihwp]

I know we are all marveling at this guy's incredible teaching skills... but do you guys ever get blown away by the complexity of the human body? I just can't get over how intelligently our bodies are designed.

[leeannstorms]

I am a retired high school biology teacher and I enjoy watching your videos so much. You truly have a gift.

[shtfckdmn]

You should be collecting my tuition payment!! This is what our lectures should look like in class.

[abdullahibrahim]

no one in thizs world can b better than this alot

[TheFarahzz]

I know that you guys hear this a lot, but I am truly thankful for these videos. It has been 3 days now in which I haven't been able to grasp this concept when my teacher has explained it and you guys were able to do it in just 20 min. Much appreciated and keep them videos coming <3

[annettecochran]

I have Lupus and watching your videos on immunology has helped me understand why it is so complicated. Thanks. Wish you could have been my anatomy instructor years ago.

[zuluzero]

Simpily amazing! My university lectures explain this in such a difficult way with 100s of slides and i almost gave up but watching your video motivated me that I CAN DO THIS!!!

[SpoonieSensei]

i have always been a little shaky on my t-cell development and this is honestly the most straightforward and comprehensive information i have ever come across. thank you!