Splicing

RNA Splicing | group 1 introns | group 2 introns | self splicing | spliceosome |

The transcription of eukaryotic gene results in formation of pre-mRNA. The pre mRNA have coding sequences and non coding sequences. The coding sequences are known as the exons, while the non coding sequence are known as the introns. splicing is a phenomonon in which the introns are removed and the exons are joined togeather to form mature mRNA. the basic mechanism of splicing is simple. the phosphodiester bond between exon and intron at 5' splice site is first broken, then the 3' hydroxyl group of the 5' exon, reacts with the 3' splice site to complete the reaction.

[sarvsoltani]

it helped me in so many ways to better understanding how exactly the splicing takes place! thanks for the great job.

[ummeabiha]

this is so far the most simplified yet the best video on the topic!!

[okankilic]

To add a minor revision, you could substitute "dash" with "prime" word. Thank you !

[rachl]

Great video! Super helpful, one thing to note is I believe the correct naming of the G and A nucleosides is "guanosine" and "adenosine" because they are joined with ribose, not on their own.

[ummulbanin]

Thank you sir for such a simple yet completely clear and understandable lecture

[joyganguly]

Really thank you for the video sir, I have never understood Splicing this good before

[rajuislam]

Thanks man.. I really get understand by your video a day before my exam.i cann't speak out how am i feeling

[SabrinaScience]

Thank you so much for this video! I'm a visual and an auditory learner and I thought your explanation was perfect!

[KarthikDisley]

simplest and shortest explanation of all, very helpful

[pakeezahashraf]

I did'nt understand my teacher's wording
But this vedio help me and make me to understand splicing easily
I just love thiss❤

[Reah]

I know I will never ever e-ever give you uuup, and I wanna say thank you in case I don't thank you enouuugh...

[apekshadandi]

It was quiet effortless to learn splicing from your video. Thanks a ton.

[alfredomunoz]

Also Prokaryotes can't have introns, because they have transcription coupled to translation. They don't have time/space for that, since intron splicing will stop the coupling. Eukaryotes evolved the nucleus, where splicing can be done

[razanfeki]

you explained something in 7 minutes that my professor couldn't in and hour and a half !!!!

[shamshassan]

thank you, you made such a complicated
process easy and clear to understand

[chloesmith]

Thanks man, I really appreciate this. Have a great day!

[Alkimachos]

am I the only one who thinks snurp is the cutest name ever?

[paige]

great video, explained very clearly thank you

[salmasanad]

thaaabk you so much i spent three days trying to understand this, fortunately i found this and i understood it quicklyy so now i wish if i have founded this 3 days ago hahaha

[extatickiddo]

I’ve never heard prime read as dash lol