Altered cognitive function in systemic lupus erythematosus

To cite: Barraclough M, McKie S, Parker B, et al. Annals of the Rheumatic Diseases 2019. Published Online First: 12 April 2019.

Objectives: Cognitive dysfunction (CD) is common in systemic lupus erythematosus (SLE) but the cause remains unclear and treatment options are limited. We aimed to compare cognitive function in SLE and healthy controls (HCs) using both behavioural and neuroimaging techniques.

Conclusions: Sustained attention was impaired in patients with SLE. Poor attenuation of the DMN may contribute to cognitive impairments in SLE and our data suggest that in addition to mood and fatigue inflammatory mechanisms and organ damage impact cognitive functioning in SLE. The multifaceted nature of CD in SLE means any therapeutic interventions should be individually tailored.

This video summarises a scientific article published by BMJ Publishing Group Limited (BMJ). The content of this video has not been peer-reviewed and does not constitute medical advice.  Any opinions expressed are solely those of the contributors. Viewers should be aware that professionals in the field may have different opinions. BMJ does not endorse any opinions expressed or recommendations discussed. Viewers should not use the content of the video as the basis for any medical treatment. BMJ disclaims all liability and responsibility arising from any reliance placed on the content.

[Kapplerartbloomingdale]

Lupus caused me spinal damage and anxiety. I have adhd and it worsened all of my psycholgical symptoms. The pain it caused, bad. I still have my intelligence.

[Hvamp]

I have SLE and over the last several days I have had dizzy spells, a feeling that I’m drugged, flush face, tingling on face etc. Last night I was laughing and got very dizzy like I was going to pass out. Afterwards I could not get my 13 year old daughter birthday right. I was completely convinced the wrong date was right. She kept saying no mom. After 20 minutes I knew her birthday again just like I always have. It made me nervous and scared as to how I could have gotten it wrong and be so convencer that the wrong date was right. Should I go for a brain scan. I know lupus can attack the brain and I’m concerned. It’s been effecting my vision too while I’m walking.

[Bubblesandcandyfloss]

Low vitamin D is common with lupus. Particularly if you’re sensitive to the sun. I have SLE. trying to bring up my vit d. It’s helped a bit.

[MzGumby]

There are days where I feel like I have amnesia or have had a stroke.

[cursedchild]

If you’re going to publish the graphs of correlations in the video you should also publish the p numbers etc. Not knowing how many possible correlations you looked at till you found one you liked makes the data kinda useless.

[yakubuyakubu]

Helping me get rid of my Lupus infection is what I will never forget in my whole life #drogoh. You're welcome to my family, thanks for saving my life .💛

[simonpreciousjoyce]

Testifying about Dr Ogie Herbal on YouTube is the great joy I have ever had in a while because, this man transformed my life In all ramification. Thanks doctor for putting an end to my lupus and putting a smile on my face again Thanks doc 🤗

[ashleygary]

I’m so excited to be cured! I’m glad I found you here on YouTube Doc Kham.

[danieljames]

I was referred to Dr. Osade on YouTube who genuinely helped me defeat Lupus completely.

[amerebumpintheroad]

Extreme flares can lead to confusion, misinterpretation of everything and personality changes and irrational reactions due to confusion and inability to be in reality