Lupus Research Reveals Specific Weather Changes that Harm Us

Lupus Research Reveals Specific Weather Changes that Harm Us

In 2019 this research was presented at the annual American Rheumatology Association and for the first time weather conditions and environmental changes were tied to specific organ flares in patients diagnosed with lupus SLE.

When the weather changes with windy conditions or temperature changes do your symptoms change? Lets talk about it!

"Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems with the diverse presentation, primarily affecting women of reproductive age. SLE can persist throughout the entire life of the patient, exhibiting possible frequent relapses. The etiology of SLE is not well understood, although the disease is known to be caused by genetic and environmental interactions. A study by Deapen et al. showed that the SLE concordance rate in monozygous twins was 24%, which was substantially lower than a prior estimation [1], indicating that environmental risk factors cannot be neglected. Environmental factors can work together to cause epigenetic changes, resulting in immune dysregulation, loss of tolerance, and autoimmunity and leading to onset or recurrence of SLE. Although many studies have evaluated susceptibility-related genes, research on environmental risk factors and the mechanisms through which these risk factors contribute to the development of SLE remains limited. Moreover, compared with the complexity and technical difficulties of gene therapy, changing environmental factors is much more practical.

In this review, we discuss environmental risk factors, including ultraviolet radiation (UVR), climate factors, and geographical distribution, in the pathogenesis of SLE and illustrate the underlying mechanisms with the goal of facilitating the development of new therapeutic strategies for the management of SLE."

#autoimmune
#lupus
#autoimmuneresearch

[CascadingCatalyst.Sikisha]

I relate to this. Especially with heat.