Diuretic (Part 07) Loop Diuretic Mechanism of Action | High Ceiling Diuretics | Diuretic Drugs

A diuretic is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way. Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of water in urine.

Diuretic drugs increase urine output by the kidney (i.e., promote diuresis). This is accomplished by altering how the kidney handles sodium. If the kidney excretes more sodium, then water excretion will also increase. Most diuretics produce diuresis by inhibiting the reabsorption of sodium at different segments of the renal tubular system. Sometimes a combination of two diuretics is given because this can be significantly more effective than either compound alone (synergistic effect).

Types and Examples of Diuretics-
(1) Examples of thiazide diuretics include:
Chlorothiazide (Diuril), Chlorthalidone, Hydrochlorothiazide (Microzide)
Indapamide, Metolazone
(2) Examples of loop diuretics include: Bumetanide (Bumex), Ethacrynic acid (Edecrin), Furosemide (Lasix), Torsemide (Demadex)
(3) Examples of potassium-sparing diuretics include:
Amiloride, Eplerenone (Inspra), Spironolactone (Aldactone), Triamterene (Dyrenium)

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[rajkanyaranher]

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[sambitdas]

I always ever grateful to you sir 🙏🙏🙏🙏🙏

[robinkrdas]

Just one word...you r really amazing teacher...

[atanudey]

Sir...
Apne 2 nd point main bataien ke they act by inhibiting Nacl reabsorption
Or ek point main .. called high ceiling caz Nacl reabsorption is high here.??

[leogaming]

All crystal clear....u explained it very well sir ...thanku so much 🙏

[sandeepbeshra]

thank u sir. i really salute u from bottom of my heart

[goodphysicalmentalhealth]

Thank u sir ....simple easy and attractive ur

[drxmanjeetkumar]

Thank you very much sir for explaining so well. 🙏

[Peanut_]

Sir apne bola ki loop diuretics ki high efficiency isliye hoti h kyoki loop of henle mai salts ka Maximum absorption hota h sir but carbonic anhydrase inhibitors k case mai bhi to PCT mai sodium ka Maximum absorption hota h phir vo weak diuretics kyu h??

[Prachiiii]

Sir u said that they inhibit sodium potassium cotransport and on other hand u said that it's symporter.??

[sometimesaditi]

thanks u sir it really help to clear my doubt

[-k.supriyayadav]

Thank you so much sir, because of you i feel this subject very interesting

[Anilk]

Sir 6th point ke baare me maine padha hai ki -
Ca and Mg will enter through paracellular space by repulsion in interstitial space. Ca, Mg, Na, Cl gets reabsorbed.
Kya ye Sahi hai??

ya fir Ca, Mg eliminate ho jata hai Jaisa ki aapne likha hai??
Please Clear Sir...
Thank You.

[waytoakhirah]

Thanku so much sir..u are really very good

[mudassirmudassirkhan]

Thank You So Much For This Video Hii I Am Dr. M.S. Khan M.D., (Psychiatry Student) From Lucknow KGMU

[arpanayadav]

Loop diuretic k savi drugs Ka mechanism of action yhi likhe kya sir ??

[arunchoudhury]

sir high ceiling diurectic inhibtion cotransport Na k 2Cl not symport
cotranspoet ki jag symport lika ha
point no. 3

[krinahirpara]

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[lokeshkuldeep]

Sir loop diuretic cause alkalosis how???
Given in kdt on 626 Page

[Vmanmeme]

Furesomide Lipid-solubility is low, and it is highly bound to plasma proteins. Explain sir???