Diuretics | Pharmacology | Dr Najeeb

#drnajeeb #medicines #pharmacology #diuretics

Diuretics | Pharmacology | Dr Najeeb

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Diuretics-Pharmacology

00:00:00
Diuretic and Natriuretic.

00:02:02
Relationship between Cardiac Output (CO) and Renal Blood Flow (RBF), Percentage of RBF ending up as Filtrate; Concept of Glomerular Filtration Rate (GFR) as a function of CO and RBF. Understanding the role of processes such as Filtration, Reabsorption and Secretion.

00:16:19
Percentage ending up as Final Urine Volume, Clinical co-relate: Oliguria, Polyuria; Nephron as the "Master Processor".

00:28:59
Diuretic and Natriuretic drugs' action on nephrons.

00:30:26
Outline: Mechanisms and sites of Reabsorption (Na+ primarily), 1-Proximal Convoluted Tubule (PCT) 2-Thick part of Ascending Loop of Henle (TALOH) 3-Distal Convoluted Tubule (DCT) 4-Collecting Tubule (CT)

00:33:42
1-Proximal Convoluted Tubule (PCT); Anatomy of PCT & mechanisms of Reabsorption, Secretion, Exchange (Na+, H+, HCO3-), Role of Na+H+-counter transporter and Na+K+ ATPases.

00:50:00
Carbonic Anhydrase (CA) enzyme, H2CO3 (Carbonic Acid); [HCO3- and H+] and the drugs that act through blocking CA enzyme (CA inhibitors); Increased Na+, HCO3- and H2O in urine: Acetazolamide.

01:00:29
4-Collecting Tubule (CT) : Principal cells, Mechanisms of K+ wasting (Kaliuretic); K+ Wasters = All Diuretics acting proximal to CT.

01:13:00
Descending LOH: Freely permeable to H2O [along with PCT]; Ascending parts of LOH + initial DCT fully impermeable to H2O, Role of ADH in CT's water permeability and excretion of dilute and concentrated urine, Osmolarities in various parts of tubule & its rationale.

01:35:56
2-Thick part of Ascending Limb of Loop of Henle (TALOH); Na+ K+ 2Cl- Co-transporter, K+ leaky channels on luminal side; electro positivity in lumen and its effect on Ca+, Mg+ reabsorption; Drugs blocking NaKCl co-transporter; Loop Diuretics [Furosemide etc.]; Kaliuretic + Calcinuria + Magnesiumurea

02:04:15
3-Distal Convoluted Tubule (DCT): Na+Cl- co-transporter, Na+Ca+ counter transporter, role of Parathyroid hormone (PTH), Thiazide Diuretics as Ca+ retaining drugs; Renal stones.

02:19:15
Comparing Thiazide Diuretics, Furosemide and their effect on Ca+ absorption & its clinical implications; Osteoporosis, Hyperuricemia. Interaction with NSAIDS.

02:26:35
Drugs acting distally to DCT; Antikaliuretic drugs: Importance of Principal cells in K+ balance, Na+ channel blocking drugs, Role of Aldosterone;

02:48:50
Effects of Diuretics on Principal Cells; Amiloride, Triamterene; K+ Sparing drugs. Aldosterone Receptor Blockers (ARBs): Spironolactone

02:54:54
Osmotic Diuresis; PCT: Mannitol; Increased Extracellular Fluid Volume (ECFV)
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[VivekYadav-bdbt]

Sir everytime u proove what u say is the crystal clear concepts....best teacher of medicine i have ever seen..

[rajatpandurangi]

Legends be this clear and still ask 'Am I clear?'. Love from India Sir

[bitsofskin]

It's such a strange thing...
I have spent MANY MANY hours (probably days if you add it all up, hey maybe even weeks) reading and studying my own health and body.
Once you start watching this Dr. and his gift of being able to explain things, the pennies just constantly drop.

Also, he also makes you feel better about yourself and your own health because of the fact you understand it all MUCH MUCH more.

Thank you Dr. Najeeb. Medical science has a gift in you.

[MuhairwaWycliff]

My name is Wycliffe from Uganda I can't get tired when watching Dr Najeeb how I wish can seat in his class when is lecturing

[chiranjibidas]

I haven't seen any teacher teaching like this very clear fundamental not only in pharma but also in physiology also 🔥🔥

[rik]

Dr. Najeeb is literally the only reason i don't give up on medicine. Super hero!!!
Thankyou

[anilkulria]

After 5 years you are still liking every comment Great

[tanimadhar]

The fact that you made me believe that even pharmacology can be understood and need not be crammed is itself praise worthy .. thank you so much sir ... Extremely grateful 🙏

[aisharasool]

I saw this lecture couple of days back and now I was revising for my upcoming exams, I just felt the beauty of crystal clear concept and just came back to video to thank you sir.. Thank you so much sir ....
I pray to Almighty to keep you always charming and blessed ...once again thank you sir

[ashifh]

I missed a teacher like you during my graduation. Thanks for making the mechanism clear and simple. With prayers.

[hanzlaamjid]

After taking your lecture, i read book, and i am like, i know everything already.
Love from Pakistan 🇵🇰

[co_os]

You deserve more than what I paid for my university tuition fee

[navaneeth_us]

26:50
56:00
1:11:20 (Recap of why some diuretics ppt keleuresis/pot. wasting)
1:34:19 - action of ADH on Collecting tubule and the deciding factor if the urine which is excreted is concentrated or diluted.

1:49:50 - How the diuretics are differentiated into high ceiling /low ceiling diuretics.

1:54:30

Management of hypercalcemia - 1:56:50
2:02:00 -
2:02:33 - Recap of furosemide

2:21:28 - furosemide v/s thiazide diuretics

2:27:30 - Principle cells
2:28:48 **- sodium handling proteins in Diff parts of nephron

Beauty of electrochemical gradient - 2:36:06
Aldosterone - 2:44:30
2:49:00 - pot sparring diuretics

[mannykamra]

Just surprised how can someone teach so well, , hats off you sir! Recently I had started watching your lectures it helps me alot 😭God bless you sir may you live long❤❤

[mbbslovers]

If we call Dr Najeeb as Father of Modern medicine, we will not do any crime,
, ,let’s call him By this name on wards, ,
Thanks a lot sir, ,, you deserve more but I don’t have words to explain 💝💝💝💝
Love from Kashmir

[suedolma]

Dr. Najeeb, i normally tell my husband that, he is the GOAT.
but you sir, are the GOAT of teaching and explaining. God bless you

[Ayeshatarranum]

Amazing knowledge, amazing memory, amazing determination sir 🎉 Allah really blessed you Masha’Allah.thank you so much for free access

[krvm]

Sirrrr U r god sent ANGEL 😇 for me
Thank u sir
Bcz of financial problems cannot take your your free videos on youtube are blessing to me🙏
Thank you for helping for students like me

[muslimrenaissance]

Who can create millions of master processors within 5 inch of kidneys other than Allah? Glory be to Allah❤️

[mohitsharma]

Turn on Mono Audio in your device settings to balance the sound on left and right channels. Thank me later.