How Long Does Prednisone Stay In Your System

#prednisone #prednisonesideeffects

Prednisone is a steroid-based medication used to reduce inflammation and inflammation-related swelling. It can take anywhere between 30 minutes to several hours to take effect and can remain in the body for up to 18 hours. It is important to consider the balance between the benefits and risks of taking Prednisone before deciding to take it, as it can have serious side effects. With guidance from your doctor, it is possible to find the right balance to manage inflammation and related conditions.

Chapters:
00:00-07:28 - How Long Does Prednisone Stay In Your System? An Interesting Answer
07:28-15:25 - The Duration of Prednisone Effects on the Body
15:26-21:28 - Understanding How Long Prednisone Stays In Your System

Key Takeaways:
1. Prednisone can alter up to two thirds of the body's genes.
2. Prednisone is a medication used to control inflammation within the body.
3. Prednisone is estimated to stay in the body for two to four hours.
4. Diet, body surface area and kidney and liver function can influence how long it stays in the body.

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*The information contained herein is for informational purposes only and should not be construed as medical advice. Please consult your physician for any health problems and before making any medical or lifestyle changes.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

[NomadMonster]

I was prescribed 20mg to be taken once in 24hr. I did that for a while... starting at 8AM in a LOT of pain, took 20mg and it took five hours before the pain would start to subside, then at about 10PM, the pain returned with a vengeance and lasted until the next dose. I switched to two doses of 10mg (morning and night) then I could at least get some sleep. With that much pain insomnia was not an issue. Now doing OK with 5mg each 12hr apart and only mild symptoms. Thanks for the series, certainly help understand.

[AngellaSpinney]

I feel that patients that are prescribed medication should know the pros and cons of what a medication can or won’t do to your body. Most patients are unaware of the prolonged effects of certain medications. Knowledge is power. It gives you the power to make a correct decision for your body. Some patients like myself had side effects that even my doctors couldn’t explain. Also we must remember that everyone doesn’t react the same to medication. Test studies aren’t done on the individual patient, which would be impossible to do. So each individual should do their own research and decide for themselves if that medication is best for them.

[rlynn]

I was on it for skin inflammation and for about 10months I gained like 50-60lbs and it took years to get off, now sadly I’m back on it😢 but I was desperate for relief

[deliajones]

I'm a nurse and took pharmacology. I have forgotten. But it all rings a bell. Hardest course for me. Corticosteroids was tested on with tricky questions. So was those half life questions

[moviebuff]

I was misdiagnosed with a condition and have been taking Prednisone for 3 months, now I'm weaning myself off of it, currently on 2.5 ml for 5 days, then stepping down to 1ml for 5 days then I will be done with it...from the information in this video I'm supposing that the side effects will be gone within a few days after I quit?

[spatelier]

Given Prednisolone seems to be frowned upon by all and sundry, I have noticed that it is so often prescribed by as a drug of last resort by many practitioners for a host of mostly inflammatory conditions. I have also read so many scare stories about its adverse side effects, but there is rarely any mention of what dose the patient is taking. I would hazard a guess that in most instances it was ridiculously high.

It is very important to understand the difference between a 'physiologic' and 'pharmaceutical' dose - a piece of information rarely mentioned including this video. The former is a dose less than the amount of cortisone produced by the body (approx 35-40mg per day). The latter is anything that exceeds it. Most problems arise with a 'pharmaceutical' dose as the body starts relying on the drug to produce the cortisone equivalent and that is why it is necessary to taper off the drug slowly to allow the body to start producing it's own again. Whereas at low 'physiologic' doses of around 5mg or less, the body is still producing cortisone, so it is possible to stay on the drug for longer periods with little of no side efferts.

As the video mentions, it is also important to note that this drug will effect people in different ways. I have found the drug extremely effective with very mild if any side effects and I have been taking it on and off for years! But other are evidently not so fortunate. For me it's a quality of life decision and I try to be sensible based on the information I have discovered about Prednisolone. I wish there was more concrete information based on proper studies but I suspect there is little incentive to do this given the patent for it has expired, so there is no money in it for Big Pharma! Plus there are plenty of other drugs to give to patients which do turn a healthy profit. However I have yet to find anything that comes close to the effectiveness of Prednisolone for my condition and it has turned out to be a life saver on several occasions.

Finally, can I suggest that those serious about researching this drug try get hold of a book called 'Safe Uses Of Cortisol' by W Mck.Jefferies. This is the most comprehensive study on the subject I have found, and will prove a mine of useful and insightful information for anyone thinking about or taking glucocorticoids. It's mainly about Cortisol but discusses Prednisolone and other man made versions. It's also full of actual case studies where patients being treated have had their lives transformed as a result . Unfortunately the book is hard to find and usually extensive, but well worth the investment if you manage to find one.

[martint]

Truly Excellent Video. Few seem to realise the difference between Blood Half Life, Tissue Life - plus the implications of P's longer duration of effect on Cells, Genes & Metabolism. (Kudos to you for clarifying this).As you point out, just because 5.5 Blood Half-Lives have elapsed, does not mean that P's effects on biology have ceased (far from it). I was also intrigued (and very appreciative) to learn - from one of your other videos - that as little as 2.5mg (maybe even less) could suppress the immune system. As you've previously alluded to - the implications for possible greater risk of Cov*id Severity (especially in the first week of Cov*id symptoms, when maximum immune function is highly desirable) is incredibly important for users to remain mindful of. I wonder what (if any) Meds / Preparations might (quickly) damp-down - or even reverse - P's changes to DNA / Genes? As Melatonin appears to be Cortisol's Polar Opposite, maybe that would help in this regard? I'm considering trying to switch to Mepolizumab, as that apparently dampens down eosinophils (which appear to be my personal respiratory nemesis). By the way, although P appears 'not' to have been proven helpful for Cov*id induced 'Anosmia', for me - taking x5mg of P for 7 Days - reverses (for about one month) my non-Cov*id chronic loss of smell / taste, thereby providing temporary relief from that awful affliction. Best Wishes from the UK.

[tahiraejaz]

I am diagnosed with PMR almost three years and I want to know how long it takes to get rid from my body 🤔

[kennethbutzer]

The health of your adrenal glands play a HUGE role in your recovery from prednisone use because let’s say your adrenal glands are very low functioning due to chronic stress or illness for years and they were already producing sub, optimal cortisol, the prednisone, which is basically synthetic cortisol is such high-dose compared to what your adrenal glands would make it automatically down, regulates your drain production of cortisol and its natural rhythms. coming off of prednisone with these issues will leave you feeling like you’d rather be dead and having to deal with those side effects. Doctors today can’t even agree on adrenal fatigue so they don’t take even a minute to consider if a person needs prednisone or adrenal support in order to support their own natural cortisol production.

[juliamcclelland]

Thanks for this channel. Prednisone although helpful for my illness has been Hell On Earth. The side effect profile is just sickening, literally.

[marilynbodasing]

Love your explanations! You make it easy to understand!

[LarsDahlin]

I have been on a one year long cure, starting dose 30 mg, taken after a 20 mg Omeprazol. I do wonder if I have to step down the Omeprazol too...

(Fun fact: The doctor wrote in my journal that I gained 30-40 kg instead of 3-4 kg. Got a good laugh together with the doctor when he found out that error. )

[mrcleanisin]

Since I feel great after the first day on methylprednisolone why do I need to continue with the rest of the pills? What is the reason to take the whole pack? I understand why if this was an antibiotic, but why for the Medro Dosepak?

[lh]

When I have a bad attack of gout I take one high dose of 50mg tablet and it’s usually gone in 4hrs!!! Amazing! I don’t have to use it very often about maybe once every 6-7 months. If I feel it coming on I cut the tab in 1/2 and 25mg and it usually works. It’s been the best thing in the world for my gout!

[adarshvats]

Due to prednisolone i suffer from insomnia last 15 days today is my last does ! When will i sleep well?

[TheFunfairfan]

Oh wow love the analogy of a tornado . Fantastic video

[mariasjostrom]

I have never had that experience. My doctors have put me on high doses 60 mg pretty much all the time. I haven't talked to my doctors and they don't speak my language. They don't ever talk to me about benefits or side effects. I'm disappointed because you would think that doctors would help you, not avoid you at all costs.

[tommoso]

Thank you so much Dr Megan, so informative. Tony from UK 🇬🇧

[rlynn]

So would a cortisol blocker help with weight loss?

[TheFunfairfan]

Have been on this 3 months due to severe ulcerative colitis, the moon face is horrendous . Have just taken my last 5mg as been on weaning dose . Do hope all this puffiness goes away