Alzheimer's Disease - Pathology, Tangles, Beta Amyloids

Please read and agree to the disclaimer before watching this video.

[Errata: In the early part of the video, I wrote recurrent function instead of recurrent infections. Please keep this in mind while studying.]

*It is an insidious, progressive, degenerative disease of the neurons.
*Alzheimer's incidence is increasing in developed nations.
*Alzheimer's disease is one of the most costly diseases to manage. Continuous care is needed, recurrent infections and dehydration are common.

Dr. Mobeen presents the pathophysiology of Alzheimer's disease. Following topics are discussed:
Anterolateral amnesia. (Loss of forming new memories.)
Speech disorders.
Mood imbalance.
Disruption of the executive functions of the brain. (Difficulty with decision making.)
Initiates at the Hippocampus.

Genes involved:
1-14 - Senilin
11 - SDLR1
21 - APP
19 - ApoE4

Alzheimer's can be early onset or late onset. Genes 19 and 21 are involved in the early onset Alzheimer's.

*Tau protein's role.
*Beta amyloid's pathologies. (A-Beta lipoprotein.)
*Role of alpha, beta, and gamma-secretase.
*Formation of senile plaques due to the beta and gamma-secretase action instead of alpha and beta-secretase.
*Immune system activation due to the senile plaque formation.
*Destruction of the brain tissue due to the inflammatory reaction due to the senile plaques.
*Clogging of the neural synapses by the senile plaque proteins.
*Loss of cytoskeletal integrity due to the disruption of the Tau proteins.
*Disruption of the nutrients flow from the neuronal cell body to the axonal terminal.
*Formation of the Tau aggregates.
*ApoE-4 gene's role is discussed.
*Widening of the sulci and gyri as a result of the degeneration is presented.
*Role of increased load of the APP protein or the gene up regulation forming APP. ...

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

[robrahlf]

The BEST VIDEO AVAILABLE!!! This gentlemen Covers everything related to Alzheimer s from genes to pathology. Awesome presentation!

[darrenwedge]

I am not a student, but my mother's sadly has Alzheimers , I feel I have learnt something from this lecture, I now have a better understanding of what's actually happening. I thank you for sharing your knowledge.

[marialock]

I am studying Dementia Disease at the moment and your explanations was a blessing. Thanks a million.

[gaylegonzalez]

This is amazing! You definitely have a talent for teaching, thank you for making this available!!

[Pegasi]

Excellent lecture! I was just listening to it, not even watching it and I still managed to understand everything through audio alone. Thank you very much!

[megha]

sir plz make videos on cell injury and inflammation also....u r videos are super hit

[carrotmeable]

Ur explanation helped made me understand a lot of holes in other lecturers explanations on the whole progression of alzheimers onset in an individual. Thank you so much!! Info will now be in my head for my final exam :)

[fikaduwotasa]

Thank you very much
this week my presentation will on Alzheimer diseases and u help me a lot.

[amulyanera]

Sir I follow ur immunology lectures ur anatomy and physiology lectures as well
Am in mbbs first year
Ur explanations helped me lot ND u know wt the cut copy paste of ur presentations in mine brought me many applause from my Dean as well.. Everyone in my college treat me as one of the most intelligent doctors but only I know it's only bcoz of u
Thanq so much sir
Thanq is a word which is not really enough to describe ur help but I can promise you that someday I will be a good doctor
But still it's bcoz of u

[techdadfranco]

You are simply great. You made it so easy. I am your apprentice from now

[Ami-ejyh]

Excellent Lecture, much appreciated. Thank you.

[maidee]

Tomorrow i will start my Masterthesis in AD-Research! thank you very much for this great and well pictured Information!!!

Helped me a Lot!
Greetings from Germany ✨

I wish you great functioning secretazes etc 😝

[ibrahimkaya]

This is very nice cover. Lipophagic dysfunction in AD would also be a chapter here.

[mashart]

Best explanation of Alzheimer's ever..thanku so much you save my time 👌

[annatomczy]

What an amazing teacher! You are a hero and this is the best video on yt. I am amazed

[themoreyouknow]

Excellent explanation
Respect from Pakistan

[Dineshkumar-cvpd]

best teacher ever.... thank you so much sir

[deepamvyas]

Very reliable explanation; easy to understand ;best alzeimer lecture ever on youtube...you make every point clear sir;thanks for helping us sir....☺

[jiaweiyu]

Detailed and easy to follow explanations! Thank you

[davidbarton]

Hi, thanks for the video. I was wondering when the cell gets destroyed through the combined work of amyloid plaque and tau tangles, what remains. Does the neuron itself disappear leaving the tau tangles and amyloid plaque behind? Or does the neuron body remain, like dead debris in the brain?