Analgesic Pathway | Endogenous Opioid System

The body has its own pain relief system that gets activated when experiencing pain.
.
As a painful stimulus ascends to the cerebral cortex (to become consciously aware of the pain) it sends signals to multiple other areas of the brain. This includes:
- Amygdala (emotion)
- Hypothalamus (flight/fight response)
- Reticular formation (arousal and consciousness)
.
1️⃣All of these regions, including the cortex, will send a signal to the
2️⃣Magnus Raphe Nucleus (located at the midline of the medulla) and will
3️⃣Send a serotonergic signal to the spinal cord
4️⃣Stimulate a neuron in the spinal cord that releases Enkaphalin (opioid)
5️⃣Enkephalin will bind to opioid receptors (delta opioid receptors) of both the pre- and post- synaptic pain neuron.
6️⃣Stopping the pain signal!!

[nimrakhan]

Dr Mike you so simply and clearly explain in 10 mins what my teachers cannot explain even after hours of lectures.

[JL-dxov]

Roger Federer makes tennis look easy, DR MIKE makes neuroscience look easy.
Quality of the great. Thank you, namaste.

[peterngangahsc]

Here in Kenya we say "asante sana" in swahili language, meaning "thank you very much" the video is educative

[Lisboacampelo]

I'm a brazilian student, and your video really helped me. Thank you, .

[colacolette]

excellent video! I've been looking for hours for the right video on ascending and descending pathways, and this is both informative and engaging! Tysm!

[gilbertocarrijodocoutofilh]

One thing is read and hardly imagine. Other different thing is see, understand and believe. Thanks, you cured my blindness about this Topic.

[howtomedicate]

Well explained video!
It makes me also think of the fear-pain-cyclus. Where fear for pain, leads to tention which causes more pain. And this pain leads to more fear, and so on.

[tarabrown]

Love your style of teaching. I teach using the whiteboard too. So helpful. I also appreciate your explanation of everything. Your videos helped me so much for my uni exams. Thank you!

[menamohamedelshehawi]

I don't know if he is a reaaaally good teacher or if its his mcdreamy look but all in all I finallyyy understood this part of neurophysiology
thank you <3

[wethenatureenthusiastssa]

Thank you so much from the bottom of my ♥

[Aya-spxe]

ماشاء الله هايل جدا هكذا تستحق لقب الدكتور

[floryriana]

bro, i read multiple lecture notes and couldnt understand a thingg. But Dr Mike just explained all of those in just 9 minutessss!!

[claregoodwin]

Thank you, great video, it's helped me to get my head around this topic

[-priyankatodkar]

It really gives a clarity about this topic, Thanks 😊

[MT_Method]

Beautiful video, just have to say that it’s not mentioned the dorsal ganglia of the dorsal root. Thanks a lot Dr Mike!

[jessicarivera]

Wonderful video!!! You're a great educator.

[DeanooMJ]

simple and direct language 👏🏻 thx a lot

[alexandrashields]

Wonderful, thanks again for an amazing and easy to understand video!

[nohaali]

Thank you, I was quite confused in this part until I watched this video

[Thomaseron]

Very educational, thank you! Wanted to know a bit more about pain relief since my cat bit me at the vet the other day. Got me thinking, if serotonin and opioids are released for pain relief that could possibly explain why some people with depression cut themselves.