Clotting factors in 1 minute / Mnemonic series #6

Clotting factors in 1 minute / Mnemonic series #6

List of Clotting Factors

Factor I

Name : Fibrinogen
Source : Liver
Pathway : Both extrinsic and intrinsic
Activator : Thrombin
Actions : When fibrinogen is converted into fibrin by thrombin, it forms long strands that compose the mesh network for clot formation.

Factor II

Name : Prothrombin
Source : Liver
Pathway : Both extrinsic and intrinsic
Activator : Prothrombin activator
Actions : Prothrombin is converted into thrombin which then activated fibrinogen into fibrin.

Factor III

Name : Thromboplastin / Tissue factor
Source : Platelets (intrinsic) and damaged endothelium (cells) lining the blood vessel (extrinsic).
Pathway : Both extrinsic and intrinsic
Activator : Injury to blood vessel
Action : Activates factor VII (VIIa).

Factor IV

Name : Calcium
Source : Bone and absorption from food in gastrointestinal tract
Pathway : Both extrinsic and intrinsic
Action : Works with many clotting factors for activation of the other clotting factors. These are called calcium-dependent steps.

Factor V

Name : Proaccerin / Labile factor / Ac-globulin (Ac-G)
Source : Liver and platelets
Pathway : Both extrinsic and intrinsic
Activator : Thrombin
Action : Works with Factor X to activate prothrombin (prothrombin activator).

Factor VII

Name : Proconvertin / Serum prothrombin conversion accelerator (SPCA) / stable factor
Source : Liver
Pathway : Extrinsic
Activator : Factor III (tissue factor)
Actions : Activates Factor X which works with other factors to convert prothrombin into thrombin.

Factor VIII

Name : Anti-hemoplytic factor / Antihemophilic factor (AHF) or globulin (AHG) / antihemophilic factor A
Source : Endothelium lining blood vessel and platelets (plug)
Pathway : Intrinsic
Activator : Thrombin
Actions : Works with Factor IX and calcium to activate Factor X.
Deficiency : Hemophilia A

Factor IX

Name : Christmas factor / Plasma thromboplastin component (PTC) / Antihemophilic factor B
Source : Liver
Pathway : Intrinsic
Activator : Factor XI and calcium
Actions : Works with Factor VIII and calcium to activate Factor X.
Deficiency : Hemophilia B

Factor X

Name : Stuart Prower factor / Stuart factor
Source : Liver
Pathway : Extrinsic and intrinsic
Activator : Factor VII (extrinsic) / Factor IX + Factor VIII + calcium (intrinsic)
Actions : Works with platelet phospholipids to convert prothrombin into thrombin. This reaction is made faster by activated Factor V.

Factor XI

Name : Plasma thromboplastin antecedent (PTA) / antihemophilic factor C
Source : Liver
Pathway : Intrinsic
Activator : Factor XII + prekallikrein and kininogen
Actions : Works with calcium to activate Factor IX.
Deficiency : Hemophilia C

Factor XII

Name : Hageman factor
Source : Liver
Pathway : Intrinsic
Activator : Contact with collagen in the torn wall of blood vessels
Actions : Works with prekallikrein and kininogen to activate Factor XI. Also activates plasmin which degrades clots.

Factor XIII

Name : Fibrin stabilizing factor
Source : Liver
Activator : Thrombin and calcium
Actions : Stabilizes the fibrin mesh network of a blood clot by helping fibrin strands to link to each other. Therefore it also helps to prevent fibrin breakdown (fibrinolysis).

Prekallikrein

Source : Liver
Pathway : Intrinsic
Actions : Works with kininogen and Factor XII to activate Factor XI.

Kininogen

Source : Liver
Pathway : Intrinsic
Actions : Works with prekallikrein and Factor XII to activate Factor XI.

[Existingua]

There is one more nemomic
Fresher's .. fibrinogen
Party.. prothrombin
Tonight.. thromboplastin
Come ... calcium
Let's..labile factor(proaccelerin)
Sing...stable factor
And...anti haemophilic factor A
Call... Christmas factor
Seniors... Stuart prower factor
Please....plasma thromboplastin antecedent
Have...hageman factor
Fun...fibrin stabilizing factor

[i_be_labrat]

Actually factor VI used to be called Quick Factor, after a guy named Dr. Quick who observed it.... as more studies evolved it was determined that Factor VI was in actuality Factor

[DrLakshmi_]

Factor 7 is stable and another name for it is proconvertin.
Rest, a nice trick 👼

[ogbulivictorifeanyi]

I wish to say thank you, your mnemonic teaching helped im my last exams, God bless you Amen and keep drooping more

[lydiaehret]

You're saving my life on this coag exam thank you!!

[lipibanerjee]

Totally useful!
Thanks
Keep uploading such videos..and along with the meaningful cartoons too ! 👍🏻

[adilraza]

Thanx a lot for giving me idea to memorise this Factors
That's Fantastic, no words to explain your explanation
Amazing

[ZXCVJe]

i always forget this clotting factors, everytime when we have a topic about this i go back to youtube always.

[algesterbenjamin]

Please make a video what is the difference between fibrinogen and fibren.. In complete information.

[ravaladarsh]

Thanks ❤🌹 a lot you save my time 😍😍😍😍😍

[easatfatema]

wow nice, very helpful.. ❣️from Bangladesh

[dharmarajsharmaroll-]

Thankyou that was very helpful, God bless you.!

[gopibeladiya]

It's a very helpful... thank you so much. 👍👍

[biowithdrchitransh]

Great work. Really made it easy.
Thanks so much for description. Keep it up👍

[umendra]

Thanks for making a tough topic so easy 👌👌👌

[FestusEs]

This is amazing, thank-you so much. It helps me capture this factors so easy and so fast. 🙏🙏

[dasariprabhukumar]

ITS a creative learning technique .that makes easy and fun to learn

[sanju_krishn_]

Number 6 kahe nhi aaya iska reason bataye...??

[Thesparklingurl]

It's very helpful.. Thanks for making this video

[VinDcator]

How does Xarelto or Eliquis fit into the cascade?