Blood Clotting Factors Tricks | Clotting Factor Mnemonics | Coagulation Factors | NEET BIOLOGY

Blood coagulation is a process that changes circulating substances within the blood into an insoluble gel. The gel plugs leaks in blood vessels and stops the loss of blood. The process requires coagulation factors, calcium and phospholipids.
The coagulation factors (proteins) are manufactured by the liver.
Ionized calcium ( Ca++ ) is available in the blood and from intracellular sources.
Phospholipids are prominent components of cellular and platelet membranes. They provide a surface upon which the chemical reactions of coagulation can take place.
Coagulation can be initiated by either of two distinct pathways.

The Intrinsic pathway can be initiated by events that take place within the lumen of blood vessels. The Intrinsic pathway requires only elements (clotting factors, Ca++, platelet surface etc.) found within, or intrinsic to the vascular system.
The Extrinsic pathway is the other route to coagulation. It requires Tissue Factor (tissue thromboplastin), a substance which is "extrinsic to", or not normally circulating in the vessel. Tissue Factor is released when the vessel wall is ruptured.

Regardless of whether the Extrinsic or Intrinsic pathway starts coagulation, completion of the process follows a common pathway. The common pathway involves the activation of factors: X, V, II, XIII and I. Both pathways are required for normal hemostasis and there are positive feedback loops between the two pathways that amplify reactions to produce enough fibrin to form a lifesaving plug. Deficiencies or abnormalities in any one factor can slow the overall process, increasing the risk of hemorrhage.

The coagulation factors are numbered in the order of their discovery. There are 13 numerals but only 12 factors. Factor VI was subsequently found to be part of another factor. The following are coagulation factors and their common names:

Factor I - fibrinogen
Factor II - prothrombin
Factor III - tissue thromboplastin (tissue factor)
Factor IV - ionized calcium ( Ca++ )
Factor V - labile factor or proaccelerin
Factor VI - unassigned
Factor VII - stable factor or proconvertin
Factor VIII - antihemophilic factor
Factor IX - plasma thromboplastin component, Christmas factor
Factor X - Stuart-Prower factor
Factor XI - plasma thromboplastin antecedent
Factor XII - Hageman factor
Factor XIII - fibrin-stabilizing factor

#Blood_biology

[realhitesh]

Loved the explanation...
Answers:-
1) b - VI
2) a - hagemen factor
3) c - VII ( SPCA)
4) c - XIII factor
5) c - BOTH
6) b - V & X
7) b - I, II & XIII

[adarshbahraich]

Thankyou sir, i am bsc nursing student and it is v helpful for me

[reetaverma]

Sir aap kitna axa explain kiye h sab clear ho gaya aaj very helpful video thank so much sir 🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏

[kaiumhossen]

Sir what does mean All and intrinsic/extrinsic.What is the difference?.

[nqqfhur]

Is this clotting factors are also important for neet exam ?
Do we have to remember this ??

[devenmoon]

What is intrinsc8 factor and extrinaic factor

[sobannizami]

Sir can you tell labile and non labile coagulation factors names

[dushyendrarajpoot]

Thank you sir
Your video is very helpful..
I am a Farmacy student

[cartoonwale]

Sir kya hum 1 or 2 clotting factor ko 7 to 12 ke saath nhi likh skte because sir inke source to same he na

[bpharmanswers]

I think this is the best video for this topic, thanks

[loneowais]

Sir
How many total clotting factors are present 13 or 12

[shilpakumari]

PLZZ sir ye bata do physiological properties of various coagulation factor me kya aayega

[garvitgarg]

Sir aapke Roman number galat likhe huwe hain..
12factors hote h...

[aarifmamadshama]

Sar me aap se baat karna chahta hu pls mere chha chha ke ladke ko himopheliya he pls help mi now

[Khushi--n]

I think hemophilic d ki jagah parahemophilic use krte h

[poojasangrey]

Thnku thnku thnku very much sir thnku so much this video is very helpful🙏🙏🙏🙏🙏🙏🙏🙏

[sureshkumawat]

1 - B
2 - A
3 - C
4 - C
5 - D
6 - B
7 - B

[Anjalikumari-hghc]

Vi, hageman factor, vii, xiii, both, v & x, i, ii & xiii
Thank u sir, I m bsc hons with biochemistry Student👩‍🎓

[studymaterial]

Answer by Asikul Sk
1. B ( vi )
2. A ( Hageman factor )
3. C ( vii )
4. C ( xiii )
5. C ( Both )
6. B ( v& x )
7. B ( i, ii, xiii )

[-sukoon-]

Answer the following questions MCQ
1. B
2. A
3. C
4. C
5. A
6. B
7. B