Tyrosine Kinase Associated Receptor || JAK STAT pathway

Video Summary:
Tyrosine kinase-associated receptor itself is a simple receptor molecule without enzymatic activity. But they associate with the Janus or Src family of tyrosine kinases. Under the resting state, the receptors exist as monomers. The binding of a ligand causes dimerization, recruitment of JAK, phosphorylation of each other and phosphorylation of receptor, recruitment of STAT, its phosphorylation, dissociation and formation of dimer, entry into the nucleus and regulation of gene expiration.

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Dr Vipul Navadiya

DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[altafalinaushad]

Short and sweet! I understand how much you have to read to make such a complex topic so easy! Let alone the superb animations!!
Thankyou so much🙏🏼

[qbzqbks]

loved it so much, very well explained thank you

[saielawate]

This is a great video thank you so much! Just one thing, I think during examples you display GH but said growth factor… small correction.

[barbarvssa]

In the video we see transphosphorylstion of jaks and receptor domains, but in the summary the transphosphorylstion isnt shown, which one is correct?

[YusufNusretKurkcuoglu]

Your thumbnails with the enzymes as guns are really tempting. Couldnt help but to watch.

[abheeverma]

Bhaut bhaut bhaut accha tha sir, apke sahare kat raha hai mbbs

[davidoluic]

HI, can you tell me here does we need 1 ligand or 2 ligands for activating this receptor? And is this receptor dimer or became dimer after ligand binding?