Apolipoprotein B (ApoB) and Cardiovascular Disease

What is ApoB?

ApoB is a protein that forms the structural component of apolipoprotein particles. ApoB is now a days being researched as an important atherogenic protein and also possibly a protein that can help identify the risk of cardiac events and strokes with better precision than LDL and cholesterol numbers. Let's understand ApoB-48 and ApoB-100.


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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.


Biochemistry, Apolipoprotein B - StatPearls - NCBI Bookshelf

APOBEC1 - Wikipedia

The microsomal triglyceride transfer protein (MTP) is involved in the... | Download Scientific Diagram

Secondary structure prediction and theoretical model of apoB on LDL. A,... | Download Scientific Diagram

Proteomic studies on apoB‐containing lipoprotein in cardiovascular research: A comprehensive review - Gianazza - 2023 - Mass Spectrometry Reviews - Wiley Online Library

Structure of apolipoprotein B-100 in low density lipoproteins - ScienceDirect

APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 [Homo sapiens (human)] - Gene - NCBI

Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target - PMC

Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. - PMC

Oxidation of Apolipoprotein B-100 in Circulating LDL Is Related to LDL Residence Time | Arteriosclerosis, Thrombosis, and Vascular Biology

Association between apolipoprotein B EcoRI polymorphisms and coronary heart disease | Wiener klinische Wochenschrift

Apolipoprotein B - Wikipedia

Can we reduce vascular plaque buildup? - Harvard Health

[mctrustsnoone]

I want to understand this more… I currently believe we have been so mislead/bamboozled by the food industry and that medicine has been corrupted by the pharmaceutical companies. Any ability to further understand biology and make informed decisions is a gift in these confusing times.

[primeraimpresionecuador]

3, 99 a momth for general public is a great idea Dr. Been!

[RBTrujillo]

Dr Been, your medical lectuers are so very invaluable!

[jewelleryaddict]

Love your lecture been watching long, long time. I have degrees in health ed. So I understand most of your lectures. Some above my pay grade. I have had chronic fatigue syndrome 30 yrs. I keep abreast of all current studies and find most newer studies are agreeing on one thing, that cortisol levels are very low in chronic fatigue syndrome and covid. I understand it has to do with fatigue but never knew does more like appetite, brain fog and depression and anxiety salt craving etc. Would really appreciate a lecture on the way cortisol does all this. Thanks.

[nickf]

I wish every one could present material as clearly as this Dr did in this video. I actually understood everything he said, and it was presented without prejudice for a position. Very well done....Thank You!

[jjjames]

Love that you’re deep diving apoB, was super excited u covered the Feldman phenomena last week & eagerly await this series thank u dr bean!🙏👍 I’ve heard tons on lipids lately but how they mechanistically cause atherosclerosis leaves me with more questions than answers usually, great start tho!

[Divinefapper]

It's nice to see you get up to date with the LDL-science. You should really try to get Harvards Chris Palmer on your show. He has done groundbreaking work on figuring out the root causes of all mental health issues, and he is successfully treating all of them with the ketogenic diet. People with treatment resistant schizophrenia have achieved complete remission with the diet, and it all comes down to our mitochondrial health. It's the same stuff Dave Feldman talks about, but in the context of mental health.

Insulin resistance and oxidative stress slowly but surely damages your mitochondria, which causes them not be able to produce ATP from glucose the way they normally do, which leads to parts of your brains to become energy deficient (which causes the illness). This can be circumvented by providing the mitochondria an alternative fuel source, ketones, which are way more easily used by the mitochondria. This restores your mental health. On top of that, ketosis promotes mitochondrial biogenesis, which recycles and repairs your faulty mitochondria + autophagy, which restores your dead cells. Autophagy is the cause why the guy who has the record fast of +380 days didn't have any loose skin after his massive weight loss; your body reused the excess skin.

[fiddlerJohn]

Great info. This is very important. Your cartoons help me to learn. Good teaching technic. Thanks. ❤

[Lohitjethwani]

Thank you 🙏 have been looking for podcasts on this topic this past week! Devine timing I guess ❤

[oibal]

Thanks again.
BTW, so glad I'm still in the control group.

[SupremeODMG]

Hi Dr been nice to see apob talk. My ldl was high in 200s and my apob is 98. My trig's, HDL, hba1c and other stuff were all low. I got worried about Apob for awhile because already have heart issues. The diet though makes me feel better than any others. If I eat any carbs heavy foods and lay down my heart palpitations are insane.

[redmond]

Yes on the monthly subscription for series. Great idea

[stephencarr]

Yes, I am interested in the $3.99 monthly fee. I rely on you to explain things I can basically understand. Almost all my knowledge of our body and medicine started just 4 years ago with the response to Covid.

[themovingintosleepmethod]

Thank you, great topic! Would be interesting to collect studies that look at the correlation of lack of sleep and apoB levels. There seems to be one study (2018) with results that indicate that SHORT SLEEP duration is strongly associated with an increased risk of elevated apoB levels in women. However, the results seem to be different for men, which raises the question of differences between women and men. Looking forward to the lectures!

[PAP_Highlands]

As always excellent video. Count me in on your proposed new monthly plan.

[mai_j]

I think the option of $3.99 a month would be a good idea. I am not a medical professional but am interested in healthspan and lifespan topics.

[logic]

I learned the importance of Apo-b in 1918 from an Italian book written by the journalist Adriano Panzironi but no mention was made at the time of the two different forms of it (48% 0r100%) From today's lecture it would appear that only the 100 form od Apo-b is susceptible to oxidation in such a way to promote plaques formation, is this a correct assumption? 🤔 It also would appear from different studies that also the Liver's receptors can no longer recognise the oxidised LDLs so instead of being reabsorbed and recycled they remain in circulation undetected. I hope all this will be discussed soon Dr. Mobeen 🙏

[leelee]

My non HDL is 189
My apoB is 125
My LDL 170
I intermittent fasting everyday for 22 hours, I am keto. I exercise 7 days a week, doing HIIT twice a week and weight training 3x at least. I eat Whole Foods, mostly organic grass fed. I am 47, 127lbs. Really not understanding how my levels can me this high.

[jlsquire]

ApoB is on the high end of normal, ldl on high end too. triglycerides low, crp normal, lp(a) low, hdl normal.
What are my risks as 60+ & female. I eat low carb (mostly meat & veges) and avoid toxins.
Getting cac score soon.

[jojoyce]

I saw a few studies on sertraline causing higher triglycerides and changes in cholesterol. Mine has been affected. I'm only taking 12.5 so it's hard to imagine it affected it. But something upped it. I'm trying to eat more healthy and increase my walk to 3 miles from one.