Virology Lectures 2024 #15: Mechanisms of Pathogenesis

The development of disease in a host, viral pathogenesis, is the outcome of both viral reproduction and the immune response. In this lecture we discuss how to measure viral virulence, and how to identify viral and host genes that regulate it. Specific mechanisms by which CD8 T cells, CD4 T cells and antibodies cause immunopatholog, and how virus infections lead to immunosuppression are discussed.

——————————— CONNECT ———————————
Twitter: @profvrr

——————————— MORE VIROLOGY ———————————

——————————— OUR SCIENCE PODCASTS ———————————

– Who Am I? –

I’m Vincent Racaniello, Earth’s Virology Professor, and I believe that education should be free.

I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

New videos are uploaded several times each week.

I do not run ads on our work as it is disruptive to learning. We depend on your support.

———————————————————————
#microbe #viruses #coronavirus #pandemic
———————————————————————

[Rene-uzeb]

38:54 that's the same curve shape as the general all cause mortality around that time. Given that child mortality is now close to zero in all cause mortality, I don't think we can conclude from the 1911 flu that child mortality was due to immature immune system.

[traianliviudanciu]

Are Sabin vaccin viruses temperature sensitive ?

[traianliviudanciu]

If antiinterferon antibody exist, did fever occur ? (If a virus infect tissue), or occur late by different mechanism ?

[christopherrobinson]

By not vaccinating for measles with the MMR vaccines, people risk losing immunity acquired from vaccination and prior infection, against serious disease and death, when infected with SARS-CoV-2. This could result in further waves of both measles and COVID-19.