Viral mutation and evolution

Viral evolution

adenine, cytosine, uracil, guanine

Darwinian evolution

Species undergo random mutation

Making most less fit

But making a few more fit

Fit means compete, survive, reproduce

Natural selection will ‘select’ the more fit

Viruses usually become less virulent over time

Increased virulence / transmissibility

Mutations that increase transmissibility

Mutations that can avoid antibodies

Mutations that can avoid vaccination defences

[justaguy]

Amazing. In less than 30 minutes you assimilated a full year of “genetics, biochemistry, virology, and immunology” in college. Great review for this old health care provider.

[gaylehorton]

I have been watching your videos for over a year now—my cat, Doodle Bug, actually recognizes your voice. He watches along side. I would have to say Doodle Bug is more informed about COVID-19 than most of my fellow Americans. Thank you for your work.

[arthunter]

Your knowledge is amazing. Thank you for sharing it...

[zapp]

Can not believe I have been watching you for over a year now. How time flies.

[lizrankin]

Thank you Doctor John. Very informative and a bit scary. We are very blessed to have you to keep us updated. I also have been following your videos for over a year now.

[QwinnieLu]

Thanks Dr C, you break things down to digestible chunks. I'm still following you after a year and still spreading the Vit D message to all that will lend an ear. I do throw in some of your other gems to mix it up a bit! Thanks for all your time and effort 😘

[bellam]

So well explained Dr John 👍👨‍🏫 I always learn so much! Love this channel 💕

[kevinoconnor]

You have a real gift for making difficult concepts understandable to laymen.

[SorinSilaghi]

"Let me stick to the viruses otherwise we'll be here forever" this made me laugh! Also, I have a feeling some people wouldn't mind 😂

[jdu]

Learnt so much this morning next to my coffee, thank you Dr John!

[sheilajones]

Thank you John for this talk today, very illuminating for me as a retired nurse. The energy you put into keeping us informed is admirable. How privileged are current health care workers to have you as a resource. How fortunate are we to have access to your calm and interesting lectures in a time when there is much disinformation and many people want to create antagonism online. I see the trolls are out in force as your blogs grow ever more popular. This has been a community i have felt honoured to be a part of for the last year, for anyone new on here take the negative comments with a pinch of salt and treat as a measure of John’s success and enjoy the wealth of knowledge available here. Stay safe everyone.

[annebierce]

Thank you so much for these videos, been religiously watching you for over a year now.You are a natural teacher to break this down into manageable segments and keep it interesting. Love the tangents and occasional rants along with the English humor.

[lennoxhelen]

Thanks Dr John for a very clear explanation of this topic and very pleased to hear from you so early in the day! Good morning everyone and enjoy the weekend.

[charmedjthreeisme]

Thank you for the continued education and information, it is much appreciated!

[kirkkitchen]

Thanks for your dedication to public health information. I have watched most of your COVID articles so far.

[beverlypearson]

I wish I had you as an instructor in nursing school way back when. You make complicated issues much more clear. Thanks for all you’re doing!

[nicolapegg]

I haven't seen any friends over the last year, but I now consider you a friend, I look forward to your support, common sense and information, i feel i have made a friend and enjoy reading the comments of your other true followers/friends xx

[nikibunga]

Good Morning Doc and yes i have now been watching you for over a year now and i am happy for that :) Thanks Doc

[aylbdrmadison]

3:22 I love that the bird flies right by his window as he says: _"All life on Earth being remarkably similar."_

I see and hear you my winged fellow Earthling. <3

[ekinseyjr]

Funny shaped person? Looks like a well-rounded individual to me. Thanks much for your work!