DNA Damage Repair No Longer a DREAM

The secret to defying the relentless march of age-related damage could be closer than we think, concealed within the very building blocks of life. The DREAM protein complex is like a cellular command center that governs the way our cells manage DNA damage, which has a direct impact on aging and the development of age-related diseases.

A study published in Nature Structural and Molecular Biology shows that inhibiting the DREAM complex, enhances the DNA repair capacity of somatic cells in worms, mice, and human cells. DREAM represses DNA repair genes in somatic cells, and by inhibiting the DREAM complex, the cells became more resistant to ionizing radiation and the effects of cancer drugs like cisplatin.

While the models used in this research may not perfectly replicate human aging, the findings offer valuable insights into the potential of reversing age-related damage accumulation by manipulating certain genes in certain tissues.

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Music: "Elastic Vibe" by Ziv Moran

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Host - Emmett Short
Producer & Editor - Ryan O’Shea
Written by - Larisa Sheloukhova, Emmett Short
Art - Mattijs Vonk, Tim Maupin
Executive Producer - Keith Comito

#DNA #DREAM #Protein #Longevity

[warioland]

I still find it odd that people considered aging to be natural when what it is is a genetic illness. It is caused by an accumulation of errors in our DNA. Repairing DNA could promote better health and overall longer life. This finding could be a potential lead in helping to treat age related diseases like heart disease.

[emmettshort]

Exciting stuff. Let’s point these LLMs at DREAM and decode this thing!

[Snipfragueur]

The problem is always making sure that the cells does not turn cancerous, right ?

[PomidorowaArmata]

But as I understood the stuff correctly, cells repair DNA anyway with success. The problem is that with each repair the cell is getting worse and worse in it's identity. That's why it becomes old and finally cancerous. What is said here is doesn't fix the effect, it might only slow down the cause.