Fasting: Reduce Inflammation | Boost Longevity- Thomas DeLauer

Fasting: Reduce Inflammation | Boost Longevity- Thomas DeLauer…

Fasting has been used as a medical and therapeutic tool for thousands of years. Intermittent fasting is a tool that is used frequently in the fitness space to maintain muscle while burning fat. The idea is to go without food for a period of time so that you deplete your immediate energy sources, ie your blood glucose and liver glycogen stores, so your body is forced into fat-burning mode. It also boosts human growth hormone, which is known to play a role in bone strength and lean body mass.

Two approaches: Full Day Fast or Daily Fast-
We are discovering that not only does IF help with fitness goals, but it also has an effect on inflammation. Inflammation is involved in many of today’s chronic conditions, including gastrointestinal diseases, arthritis, obesity, asthma and cancer. We experience inflammation when our body is trying to heal itself, but when the reaction becomes chronic, negative health impacts occur.

Fasting and Inflammation-
Inflammation is a major cause of musculoskeletal disorders, ranging from short term back pain to arthritis and osteoporosis. One study on rheumatoid arthritis found that fasting reduced the inflammatory symptoms of RA. 14 individuals with RA were studied before and after a 1 week fast. It was found that fasting reduced the release of leukotriene B4 from RA neutrophils, reduced the generation of cytotaxins from serum and altered the phospholipid fatty acid composition. Leukotriene B4 (LTB4) plays an important role in several cellular processes involved in inflammation, including oxidative metabolism, enzyme release and stimulation of neutrophil migration and aggregation. It is known that altering your lipid intake changes the phospholipid fatty acid composition of cell membranes. This has an impact on the precursor substance content for the production of inflammatory leukotrienes. It has been shown that a diet high in fish oil decreases the production of LTB4, so this experiment wanted to see how total calorie reduction would impact this. It was also shown that the phospholipid composition changed with a resulting reduction of LTB4 production. No adverse effects of fasting were found in the study, only lightheadedness and a bit of weakness during the fasting period.

Several other studies have shown that a calorie restriction diet, which is reducing your calories without malnutrition, reduce inflammatory markers. This occurred through the reduction of inflammatory cytokine production, including reduced tumor necrosis factor and interleukin-6.

Studies have shown anti-inflammatory effect of CR on the brain tissue (hypothalamus), serum, liver and heart. Chronic inflammation can harm every part of our bodies, including the brain. Chronic neuroinflammation is typical in many neurodegenerative diseases, including depression and Alzheimer’s. In a 2015 study on rats it was found that IF reduced the risk of damage to brain function in both younger and older rats when looking at neurodegenerative diseases linked to central nervous system inflammation. Researchers at the Yale School of Medicine conducted a study on mice in 2015 and found that beta-hydroxybutyrate (BHB) produced by fasting inhibits NLRP3, a set of proteins known as the inflammasome. The inflammatory response in several disorders is driven by the inflammasome. These disorders include auto-inflammatory disorders, Alzheimer’s, type 2 diabetes and
autoimmune disorders. BHB is produced when you fast, consume a ketogenic diet, do high-intensity exercise or experience calorie restriction.

References:
1. Role of therapeutic fasting in women’s health: an overview

2. Effects of fasting on disease activity, neutrophil function, fatty acid composition and leukotriene biosynthesis in patients with rheumatoid arthritis

3. Calorie restriction with a high fat diet effectively attenuated inflammatory response and oxidative-stress related markers in obese tissues of the high diet fed rats

4. Effects of intermittent fasting on age related changes on...in rat hippocampus

5. Auto-inflammatory mechanism of dieting and fasting revealed

[plantmama]

When you said “your body wants you to feel good” I wanted to cry. After having RA for 8 years now and various ugly skin rashes I’ve always thought my body hated me and wanted me dead… But you’ve given me hope. Thank you.

[colettebatman]

Yes! Before watching your vids I fasted for 4 days and inflammation was reduced significantly! Watching your vids has changed my life...eliminated soy products...increased healthy protein mostly fish and eggs...healthy fats...turmeric 3x daily...calcium/mag before bedtime and slept 8 hours! Lastly...DHEA taken in the morning...I am pain free...can't believe it!! I'm 49 and feel in incredible!💪☺️

[FreedomVibeArt]

I have had really great results with as little as 36 hours of fasting. The most I've done so far is 72 hours. Its helped me in the following ways: (1) reduce or eliminate inflammation (mine is mainly in my lower back.) (2) Increased mental capacity - I can think more clearly, and I can process more sensory information at once. (3) General sense of well-being. My mood and sense of well being increases dramatically. (4) More internal fire - I feel more confident, motivated, courageous and focused in terms of my own work.

[MILTICO]

Please don't dumb them down. The major reason I subscribed and started watching all of your videos is because of the scientific details like, specific enzymes, metabolic pathways, and getting deep into were all is coming from. This is the only fitness channel that I can say it's completely worth sitting down and actually listen to every detail. Keep up the good work.

[MarkrRetacco]

I need a hip replacement. After fasting I feel so much better. This man is amazing.
God Bless you Tom for helping so much of us. I appreciate the science behind it.

[febbiegrace]

A group im on keeps talking about doing 3 day water fast. Decided to try for myself for 1 day. Felt good, no hunger or any migraines, still have a lot of energy. Decided to do 1 more day. Now its Day 5 for me :) Im listening closely to my body. Told myself that if I ever feel any extreme headache, nausea or starving or any scary symptom then Im going to break my fast, but so far I just feel energetic and a lot of clarity. I continue to do daily yoga too. A big plus is Ive lost 8 lbs.

[theonlykog]

I water fasted for 8 days. I did two workouts a day for an hour each. The results were amazing.

[livm.]

Starting fasting and noticed my arthritic knee hasn’t been bothering me. Decided to look this up and your video popped up. I’m determined to continue intermittent fasting!

[luvleeyoga]

just started intermittent fasting 8 days ago, and I've noticed less inflammation in my joints it's great 🌞

[kellikay]

I have been fasting for 21 hours a day for the last week. I don't do a full 24 hours, but I have noticed the inflammation in my hands has been reduced at least by 50 percent.

[paulelliott]

Don't dumb them down. People just need to think harder.

[SonnySkye]

I've recently been diagnosed with inflammation in my body. It got so bad it was affecting my heart and muscles. I'm going to try this. Thank you

[schellingrs]

When I intermittent fast daily for 17+ hours, my lower back pain and inflammation goes away!

[Deyonkersny]

I have pancreatitis and i just started fasting and i'm feeling better.😀

[wesleybecker]

I fast 36-40 hours every other week and 72-96 hour range twice a year. It's been miraculous for my health.

[devoragray]

Please don’t dumb-down the videos. You’re one of the only ones who supply them on a regular basis in league with training and fitness. I would much rather know where to look at the CURRENT research than just listen to people on pure faith. Love your content. Thanks for all the hard work you put in the channel.

[eyelwin]

First off id like to say thank you Thomas, my name is Colin Craig i'm from Winnipeg, Manitoba, Canada. I got married recently and 6 months before this date i came across your channel and i was off to the races! i lost 65 pounds in the next 6 months. now that the goal i did reach by that 6 month period was over, i now have dropped off the intermittent fasting and total kito eating plan. i would appreciate some words of encouragement and some steps i can take to do this lifestyle change that will stick with me for the rest of my life. thanks for everything you've done for me and everyone. your truly an inspiration.

[CindyCyndiCinde]

I'v been told that I had to eat first thing in the morning and every 3 hrs whether hungry or not to loose weight, i have personally not seen any result with weight-loss unless I fasted,

[yipperdeyip]

I'm actually doing my first 24+ hour fast right now!
I'm 40 or so hours in at the moment! :)
Feels absolutely exhilarating!

[TheConcussion]

Fasting is the best thing ever!!! Thank you for this video, very informational.