Cystic fibrosis pathophysiology | Respiratory system diseases | NCLEX-RN | Khan Academy

Created by Amy Fan.

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[preyesrn]

This explanation of CF is so comprehensive, thanks, really helps for my patho class.

[pedrooliveiramonteiro]

HALLELLUJAH! A simple explanation of how chloride, despite being low in every other exocrine secretion, is high in sweat!!! Thank you !!

[Orangesoda]

Spent too much time talking about the skin effects and not enough time talking about the pulmonary effects, which are more pathologic.

[sciencenerd]

I learned a lot. Thanks so much Khan Academy!

[CFlifestyleFoundation]

Thank you for sharing this information.

[havvanurozekici]

I've watched this video in order to learn about CFTR but what happened? Then I learned that in sweat glands CFTR mediated the movement of Cl from outside of the cell to inside; but in lungs, CFTR makes Cl- ions to go to the outside from inside. I don't know. I'm confused. My sources: Wikipedia and Pubmed.

[yogayantra]

thank you. So is cystic fibrosis pathology = mucoviscidosis???? Thanks for your reply. [NB: i am a student]

[helenaalvarez]

I finally understand this now, thanks to you! Cheers  xx

[elijahsmith]

So the difference between the sweat glands and everywhere else is you have decreased Cl- reabsorption in the sweat glands causing salty taste, and increased reabsorption of Na+ in the respiratory, GI, reproductive causing thick secretions.

[albrestevez]

I don't get it. You say In normal CFTR your get NaCl- outside because their channels work fine. In mutated CFTR if Cl- cant get out of the sweat gland and Na+ neither because Cl- channel is closed and Na+ follows Cl-, then how are you gonna get more amount of NaCl- outside???

[AhmedMD]

So beautiful! thanks a lot.BTW what is the name of the app you are using for painting and typing in this video?

[STF]

How did the chloride get in the sweat gland at the first place ?

[kjonesusmc]

I wish I had your handwriting... I wish Sal Khan had your handwriting haha.

[roseb]

This isn't very useful by itself- salty sweat isn't the major issue with

[hoalethi]

the sound is not good I am quite disappointed

[geromepaule]

the writing is very disturbing (i mean the sound) arrggg

[eviedson]

Lol, this video kinda sucked there's so much more to it. I'll stick to my textbook!

[rayyanabuoliem]

your sound very smart
that I got turned on watching a Pathophysiology video
What a time to be alive
thank you Evolution for making smart girls!!