Tissue Plasminogen Activator (tPA) - Uses - Hematology - Pharmacology

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This is known as thrombolytic therapy, useful for myocardial infarction and ischemic strokes, but contraindicated in hemorrhagic strokes (due to increased risk of bleeding).

There are absolute contraindications as well as relative contraindications to fibrinolytic therapy (tPA, alteplase, streptokinase,...etc).

[davidmbeckmann]

I am old enough to have used both Streptokinase and TPA for acute myocardial infarction. Probably treated 20 plus before angioplasty took over. You had to use Streptokinase right. 1.5 million units over 30 minutes, instead of 60 minutes...this was rock and roll Strepto from protocols developed in New Zealand. The guys would groan, " I feel terrible ", roll onto their sides, vomit, and... reperfuse. I loved it, much more dramatic than the slow TPA protocol. Being in a community hospital about 60 miles from tertiery centers, I still drill with the TPA protocols because sometimes the choppers don't fly and on those days ground transport ain't humming either! Cheers!

[hindhind]

شكرا كتير انت سبب نجاحي بامتحان الascp بعد انقطاع ١١سنه

[ronnazhou]

NCLEX-RN tip: contraindication of tPA starts at 13:48

[ionictotalwar]

im watching all 121 videos rn for USMLE

[shang]

what other intravenous medication for the stroke except TPA please ?

[sivav]

@MedicosisPerfectionalis can plasmin break chronic blood clots which has organized or calcified in artery?

[barjees]

Where can i find your video on stroke ?

[ronnazhou]

"uh- we have another hour to.." "s-h-u-t. u-p."

[A_b_loveA_b_love]

Why we lysis fibrin by plasmin but on otherhand we need fibrin for cloting

[leggy]

So here's a question for you, if Pharmaceutical companies don't increase prices to 'what the market will bear', why do patented drugs in Europe cost only about 20% of what they cost in the USA? Even drugs off patent are about half as expensive in Europe. Answer... Because the pharmaceutical companies are limited in how much they can charge in Europe and other countries too. Not so in the USA, where they raise the prices to what the market will bear, lol... I do appreciate your point though about why localized fibrinogen drugs are more expensive!