A Tale of Two Sugars – Dr Richard Johnson - #CoSci

Dr. Richard Johnson, a renowned professor of medicine, delves into the biological mechanisms behind obesity and related diseases in his presentation, "A Tale of Two Sugars." He explores the impact of fructose, a type of sugar found in fruit and added sugars, on metabolic health and how it drives conditions such as diabetes, obesity, and Alzheimer's disease. Johnson explains how fructose triggers hunger, insulin resistance, and fat storage, and contrasts this with allulose, a natural sugar substitute that offers potential health benefits without activating the harmful metabolic pathways associated with fructose. He concludes with insights on the role of diet, particularly low-carb and ketogenic diets, in preventing and managing these diseases.

0:01 - Introduction to Dr. Richard Johnson
0:24 - Opening Remarks
0:46 - Obesity and Diabetes: An Epidemic
1:07 - New Associations of Metabolic Syndrome
1:20 - Questioning Bad Habits as Causes
1:45 - Nature's Lessons on Obesity
2:28 - Biological Activation in Animals
3:30 - Fructose as a Biological Trigger
4:31 - Fructose and Metabolic Syndrome
5:23 - Fructose in Fruit vs. Added Sugars
6:06 - Body's Production of Fructose
6:56 - Mechanisms of Fat Storage
7:47 - Impact of Fructose on ATP Levels
8:32 - Glucose vs. Fructose Effects
9:04 - Uric Acid: The Key Driver
9:39 - Fatigue and Energy Misconceptions
10:05 - Fructose and Alzheimer's Disease
11:17 - Risk Factors and Memory
12:12 - Sugar Intake and Brain Size
12:53 - Fructose in Lab Rats
13:07 - Neurological Impact of Fructose
14:05 - Blocking Fructose Metabolism in Animals
15:04 - Fructose Levels in Alzheimer's Patients
15:51 - Role of Uric Acid in Dementia
16:43 - Fructose and Behavioral Disorders
17:56 - ADHD and Bipolar Disorder
18:59 - ADHD as a Foraging Behavior
20:04 - Bipolar Disorder and Fructose
21:23 - Solutions: Diet and Lifestyle
22:39 - Allulose: A Healthier Sugar Substitute
24:19 - Benefits of Allulose
25:54 - Impact of Allulose on Diabetes
27:28 - Cognitive Benefits of Allulose
28:48 - Conclusion: The Tale of Two Sugars
30:09 - Q&A Session on Sugar Addiction
31:11 - Final Questions and Closing

[cleancutguy]

It's always best to avoid consuming any type of sugar, it's hard to quit because it's an addiction. It took me almost two months to quit sugar, but the benefits are many. I lost 15 lbs, cleared up my skin, and slept way better, dandruff gone clear mind

[mr]

Since I started studying metabolism a couple of months ago my intuition was that fat storage was an evolutionary response to scarcity of meat. I’ve been asking on various channels but this is the first time I’ve confirmed it with this excellent and thorough explanation. This Doctor is now in my top 5 along with Dr. Bikman.

[livincincy]

The Caloric Baseline used in the Minnesota Starvation experiment in WW2 was based on studies in the 1920’s & 1930’s. An average American Male was 5’6” and weighed 143#. Their average caloric intake was 3500 per day. Higher activity and being outdoors in the winter required more calories. The US Army determined men needed 8-10k if living outside in the winter to maintain weight.

[KimbaRoars]

Very compelling information in the first 75% of the presentation. So I’m thumbing this up 👍🏽 And then he starts to sell another sugar substitute. My last sugar substitute (which I’ve used for 20+ years) was Stevia. The non-commercial slightly bitter stevia. They said it was “natural.” Until I eliminated it. It still causes a desire for sweet. And that desire is longer lived than one might think. I can’t imagine yet another “miracle” sweetener is going to prove beneficial long term for anyone who is of addicted behavioral patterns, which is probably 95% of the American population. I believe eating as if all of these processed, GMO, non-foods, hybridized grains, fruits and vegetation did not exist the way it was 150+ years ago, is the way. But I’m sure I’ll have a piece of cake (that I’ll make at home) on my birthday. Everybody’s looking for something to fill in the hole. Discipline equals Freedom.

[DCGreenZone]

Fructose blocks the conversion of D3 into its active form. Credit, Dr. Roger Seheult.

[ohrein]

Now please someone compare keto and a high carb diet where fructose replaced with allulose. And then compare keto and keto with allulose. ... And what about the sweet taste? Doesn't the sweet taste (even in the absence carbs) provokes insulin secretion? ... So allulose is naturally present in some fruit in small amounts along with glucose and fructose. Shall we consider a pure, extracted allulose as a highly processed food? ... Allulose? No, thanx, I'll stick with real low carb food.

[rogerweigel]

Just cut out the sugar, carbs and seed oils

[laurengarfield]

Allulose caused a severe liver response. 3 day hospital stay, lot’s of pain.

[DrAJ_LatinAmerica]

Love Dr. Johnson's work. Now we need to get him healthy, keep him healthy and working out with Dr. Baker.

[tonyprice]

The issue for allulose is that it doesn't encourage lower overall consumption. So people will tend to continue to over eat even if fructose is reduced. Not good for them or the planet. This is likely why weight loss using alulose is inconsistent. Just ditch the starchy carbs and sugars.

[golaoi]

Dave, that was marvellous. I knew a lot of it already but this tied it all together. One of the best talks I've seen.

[koumudiketkar]

Great info, Dr Johnson & thanks to Dave for bringing it to us! ... Anil

[ChadRD]

Yeah, not really. I know many people, including myself that eat quite a bit of fruit but are able to remain lean and not overeat.

[livincincy]

Thanks Dave.

I respect him disclosing he works for a company making a Fructose substitute.

I am not sure I agree with making a “ food “ that substitutes for fructose and uses human addiction as a marketing method.

[anomarnamloh]

Yippie! Happily anxious to hear this!

[LivingRadiant]

Agree, great presentation. I’m learning a lot!
The fear is if I start eating sweets, even allulose, I’ll consume more food? … because I love sweets. I better stay out of that. Doing low carb for a year by now, no refined sugars, forgot what it taste like 😃

And I totally believe in cognitive health improvement with no sugars in my diet!

[anjaplazoniccoulson]

Fantastic lecture!!! Of course, I don't plan to use allulose. But every bit if data presented is so valuable! Thak you!!

[Joe_C.]

So if increased uric acid is the primary driver here, would the detrimental effect be similar from consuming high protein? 🤔

[ferminromero]

Outstanding presentation! One of his best to date.

[CashMoneyMoore]

So interesting that even when not consuming fructose, fructose can still be a problem