Scientists Discover the Holy Grail of Longevity? Blocking IL-11 To Reverse Aging & Extend Healthspan

Professor Stuart Cook talks about blocking Interleukin-11 reverses multiple hallmarks of aging. This therapy may have the similar effects of combination of rapamycin, metformin and senolytics. The IL-11/ERK/mTOR axis of senescence is a therapeutic target for extending mammalian healthspan.

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

Understanding interleukin 11 as a disease gene and therapeutic target

Blocking Inflammation Protein Extends Lifespan

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DISCLAIMER: The information and opinions expressed in this video are for informational purposes only and are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult with your doctor or other qualified health provider before start taking any supplements.

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[ReverseAgingRevolution]

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[geldoku]

new teeth and now age reversal !!! I need this stuff today.

[antoniobortoni]

Haha, so let me clarify: if we produce these antibodies in large quantities, we could have a serum that needs to be injected periodically. This serum targets and blocks IL-11, a molecule that increases and becomes problematic as we age, contributing to inflammation and fibrosis.

Unlike genetic treatments, which are expensive and complex, this antibody treatment could be a more accessible option. While it won’t literally make a 60-year-old feel like they’re 20 again, it could significantly improve health by reducing age-related inflammation and damage.

Additionally, this treatment could be a game-changer for those suffering from fibromyalgia and chronic pain, offering much-needed relief by addressing the underlying inflammatory processes.

Nice

[incognitotorpedo]

I've been following life extension for a long time, and I think this one is important. Boehringer Ingelheim has an anti-IL-11 monoclonal antibody, currently known as BI 765423. There is a Phase 1 trial going on at the moment, which is just looking at pharmacokinetics in healthy males. It's still a long way from approval. That will require a Phase 2 and Phase 3 trials, which will take years. The paper described here is going to generate a lot of interest in this mab and any other possible IL-11 antagonists.

[darkhorseman]

Il-11 levels increase in response to age related accumulation of iron.

It does this to stave off iron loving bacteria.

If you block IL-11 you do help with regeneration, but you compromise immunity. It'll work in a lab but not in the real world.

Better off lowering age related iron accumulation.

[Redranddd]

Where is the comment of that guy that has been talking anti IL 11 for 20 years?

[MMPRECISIONPAINTING]

What natural interventions can one take to reduce IL 11? Diet, etc.!

[nappingnomads]

Great! now where can I buy some anti IK-11?

[Your-Lver]

Inhibition of iL-11 will be problematic because it can directly affect the somatic cells and blood cells. Also, this is a crucial cytokine and receptor needed for maintaining fertility.

[maxhunter]

Anyone know what the anti il-11 actually is? Where did it come from? Does it have a natural analog? Or are there other ways to inhibit il-11?

[the_overthinking_philosopher]

How do we get anti IL-11 over the counter therapies?

[sebek]

🎯 Key points for quick navigation:

00:00 *🧬 Introduction to IL-11: A less-studied cytokine, profibrotic, anti-regenerative, and pro-inflammatory.*
00:29 *🧪 Research Overview: IL-11 found highly upregulated in fibrosis-related conditions.*
01:39 *🧹 Kidney Regeneration: IL-11 inhibition leads to kidney function restoration in mice.*
02:08 *🔬 Epithelial Regeneration: IL-11 inhibition promotes epithelial cell-driven kidney regeneration.*
02:22 *🧩 IL-11 and Inflammation: IL-11 induces pro-inflammatory responses in kidney fibroblasts.*
02:50 *⏳ IL-11 and Aging: IL-11 stimulates a pathway leading to aging and cellular senescence.*
03:18 *🔄 Pathway Activation: IL-11 activates ERK, leading to inhibition of LKB1 and activation of mTOR.*
04:12 *🧬 Aging Gene: LKB1 is an important gene in aging; its gain of function is beneficial.*
04:52 *🧪 IL-11 in Senescence: IL-11 inhibition reverses cellular senescence and inflammation.*
05:44 *📉 Age-Related Increase: IL-11 levels rise with age in various organs, activating aging pathways.*
06:40 *🧬 Genetic Study: IL-11 receptor knockout mice show significantly younger biological age.*
07:50 *🐭 Mouse Study: IL-11 inhibition reduces frailty and maintains muscle mass in aged mice.*
09:12 *🧠 Brain Atrophy: IL-11 inhibition reduces brain atrophy in aging mice.*
10:36 *💊 Potential Therapy: IL-11 inhibition as a single agent could target multiple aging pathways with limited toxicity.*

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[EverybodysSenatorUS]

Super Major Breakthrough especially at end of video combo therapy with other anti aging supplements

[DCGreenZone]

Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases
>>Moreover, in an in vivo experiment, a preparation containing the essential turmeric oils in addition to the standard Curcumin demonstrated a higher bioavailability, a prerequisite to be adsorbed following the ingestion, resulting in upregulation of the expression of IL-10 and IL-11. Taken together, this preclinical and clinical evidence allow considering Curcumin and its derivatives as a tool to potentiate the chemotherapeutic agents against cancer.<<

[julietalovra]

Amazing discovery! Thank you for sharing it 🥰🎉

[newyorkskier]

Great presentation. So easy to understand

[josejr.]

This IL-11 seems go to the main stream news already. I just found Dr Sinclair talks about this in his twitter as well.

[workingTchr]

The only drawback of NMN supplementation found so far is fibrosis of kidneys in elderly mice. If anti-IL-11 stuff can "undo" kidney fibrosis, us elderly mice can go back to taking NMN without worry.

[ginadani]

The oposite of lnterleukin 11 is il2 and you can find in omeopathic form from GUNA ITALIA .is an alternative?

[Sleepdriver]

Being itself also a growth factor recruiter and essential in cell proliferation, IL-11 should not be blocked unless one is already 60-yo