Diabetes Mellitus (Part-03) Insulin | Pharmacological Action & Mechanism of Action of Insulin

Diabetes mellitus is a disorder in which blood sugar (glucose) levels are abnormally high because the body does not produce enough insulin to meet its needs.

Type 1 Diabetes Mellitus
In type 1 diabetes (formerly called insulin-dependent diabetes or juvenile-onset diabetes), the body's immune system attacks the insulin-producing cells of the pancreas, and more than 90% of them are permanently destroyed. The pancreas, therefore, produces little or no insulin. Only about 5 to 10% of all people with diabetes have type 1 disease. Most people who have type 1 diabetes develop the disease before age 30, although it can develop later in life.

Type 2 Diabetes Mellitus
In type 2 diabetes (formerly called non– insulin-dependent diabetes or adult-onset diabetes), the pancreas often continues to produce insulin, sometimes even at higher-than-normal levels, especially early in the disease. However, the body develops resistance to the effects of insulin, so there is not enough insulin to meet the body’s needs. As type 2 diabetes progresses, the insulin-producing ability of the pancreas decreases.

Complications of diabetes
(1) Brain, causing a stroke
(2) Eyes (diabetic retinopathy), causing blindness
(3) Heart, causing a heart attack
(4) Kidneys (diabetic nephropathy), causing chronic kidney disease
(5) Nerves (diabetic neuropathy), causing a decreased sensation in feet

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[waheedahmed]

Genius professor
Pharmacy professional, s friend

[seemaramteke]

A big big thanks The way u teach in more simplified manner is really helping me a lot to understand the Plz keep uploading the videos

[akashparekh]

dear sir,
your are doing great work by sharing knowledge as well as explain hard pharmacology word in to simplified manner. truly great job.
actually after 5 year of m.pharm i am prepared for PEBC exam and this all videos from general pharmacology to anticancer drug are very helpful and clear my concept.

[b.pharmagaming]

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[vishalagale]

Thank you sir ... Your videos are very very very helpful to us ... Your style of teaching is also awesome ❤️ ... Thanks once again 🙏

[mayuripatil]

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[wkgptuh]

❤️ आपका तहे दिल से धन्यवाद ❤️
🙏🏻 🙏🏻

[MahmudulHasan-eplt]

Very good video for pharmacology class.... Thanks for this

[rzkhan]

Really ....boht hi accha ...thnk u so much

[SunitaSharma-fbgl]

Thank u sir your vedios are very helpful for us .

[imranshuttari]

Wonderful explanation sir
But sir you didn't tell glucose transport GLUT 1234

[pharmacyeasy]

sir your all video is best and most inspire for me....
..thank you sir

[dushyantkukrejafanclub]

Thanks for uploading it sir, I was eagerly waiting for this one, plz do upload further more videos regarding this unit rapidly ..

[istutisrivastava]

Sir agr pharmacogy of nsaids puche qn mai to usmaj kya kya likh sakte haii 10mm ka hai

[Harryonthebeat]

Very good video, aap best explain krte ho, but i am sad k yeh mujhe final exam k pehle milli 😓

[mahroofbabu]

Recombination is a process by which pieces of DNA are broken and recombined to produce new combinations of alleles

[samarthsangtani]

Sir is this mechanism enough for 5 marks question or we should refer KDT mentioned mechanism?

[azharsiddiqui]

इंसुलिन की डोज कैसे डिसाइड की जाती है अगर किसी पेशेंट शुगर लेवल 450 है उसे कितना एंसेल्म दिया जाएगा

[sabashireen]

Sir is oral hypoglycemic drugs and oral antidiabetic drugs same ? Just a minor confusion help me out please

[shahzadalam]

Then who regulates the level of insulin in brain, liver, WBC, RBC, as less or high insulin can cause harm to these parts ?