CRISPR Immunity Explained: How Cas9 Protects Bacteria from Viruses

CRISPR-Cas9 is well-known as a genome-editing tool that lets scientists rewrite DNA, but it originally evolved in bacteria. So what does CRISPR do in nature? And by what mechanism? This animation explains how the CRISPR-Cas immune system works to defend bacteria from viruses called bacteriophages.

Animated by Janet Iwasa for the Innovative Genomics Institute.

[ksideth]

Many thanks for such a descriptive video.

[attahussain]

thanks maam, love from Sindh, Pakistan

[JOSELUIS-oeln]

Good afternoon. Congratulations for the video. There is one thing I do not understand. How does the viral DNA fragment integrate into the bacterial genome? Thank you.

[zc]

what I don't under stand is, the viral genome was already cut in the first place, before a particular spacer is formed

[tko]

What i don't understand is how dosen't this system also cut out the viral DNA already integrated in the bacteria genome (flanked by CRISPR) and thus inactivating the bacteria response in the future

[HNOO]

so whos cataloguing the strands between the repeats and checking against known viruses to see if answer out there already for one we havent solved ?

[tgifford]

Will CRISPR be able to correct gene mutations (i.e. JAK2V617F)?

[SudartiDarti-oyjz]

gae robot ae petrous bank ceramat tidak mau berubah yo takok isteri ku bapak e pat cay seng denger locasinne