Antifungal Drug (Part 02)= Classification & Mechanism of Action of Antifungal Medicines | Antifungal

An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually obtained by a doctor's prescription, but a few are available OTC (over-the-counter).

Antifungals can be grouped into three classes based on their site of action: azoles, which inhibit the synthesis of ergosterol (the main fungal sterol); polyenes, which interact with fungal membrane sterols physicochemically; and 5-fluorocytosine, which inhibits macromolecular synthesis.

Polyene Antifungal Drugs
Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside.

Azole Antifungal Drugs
Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function.

Allylamine and Morpholine Antifungal Drugs
Allylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step.

Antimetabolite Antifungal Drugs
5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

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[ParthBambhroliya]

Sir thank you for very nice classification and informative images.
I want to highlight few mistakes
1. In classification of azoles, it's actually Triazole not diazole according to kd tripathi and goodman gillman book.
2. Drugs acting on nucleus is flucytosine not flucyosine.

[madhav]

"India's NO.1 Pharmacology Youtube Channel For Pharmacy Student."💐🙏

[daxhingfani]

I passed my pharmacology exams just by watching your videos. Thankyou so much sir. Continue teaching us in same way. God bless you

[moujmastiharra]

Sir itna clear kisi ne nahi samjhaya abhi tak

[UKEase]

Nice explanation sir you deserved Oscar ❤❤

[ShabirAhmed-ovql]

Thank you so much Animation video ... Sir gi all concept

[AmritKumar-bleu]

Thank you, This video is most informative for me and also understand completely

[ahsansheikh]

Very good job sir 👍. It really help me in understanding this topic.

[siddhimane]

Crystal clear concept ...have my respect sir👍🏻

[drs.s.samir-]

Animation is the Best process for simply learning

[tusharkesarwani]

Sir here in the classification of Azoles there is IMIDAZOLES and TRIAZOLES in KDT book... But sir u have written Diazole ..please explain sir

[omkarsheelvanth]

Thank you so much...Sir🙏
For this animation video..

[prashantyadav]

Thank you much sir for your efforts sir salute you sir❤🎉🎉🎉🎉🎉

[timewithtarun]

Good evening sir
I am very confused regarding the pharmacology and medicinal chemistry.
I am b pharmacy 4 sem student. Pharmacology and medchem is new for us. The classification is different in both subjects. I am confused in which classification should I learn?
After the completion of my b pharmacy. I have decided that I will give government pharmacist exams. So as per your experience which classification is asked in the competitive exams, I mean they asked the drugs name according to their pharmacological action or on the basis of the chemical class?


And one more thing u teach pharmacology very well. I studied pharmacology of ANS from ur videos. Thanku so much from bottom of my 🫀🫀🫀🫀🫀🫀 Thanks again to both of u sir and pharmacognosy mam .

[abhishekchandra]

Thanks sir your teaching very intresting

[royalpharma]

Great work sir
Good explanation thankyou

[akhadehr]

Sir THANK YOU SO MUCH FOR THIS VIDEO 🙏🙏🙏🙏

[mdhurisingh]

Sir fluconazole, itraconazole previously you included in diazole after that triangle???