AntiFungal Drugs PART-2 ||Mode of action,uses,||Amphotericin B||Medicinal chemistry-3 ||

CONTENT OF THIS VIDEO,
Introduction
Classification
Mode of Action
Synthesis
Uses
Adverse effects

ADDITIONAL TAGS:
glucans
chitin
ergosterol
DNA synthesis

SUBJECT-Medicinal Chemistry-3, Pharmacology3.
For B.pharma,D.pharma.

This is a brief overview of antifungal agents, their
mechanisms of action, and some fungi that they affect.

Antifungal
Polyenes (such as amphotericin B) bind ergosterol,
weaken the membrane, cause pore formation, leakage of
K+ and Na+, fungal cell death; also confers mammalian
toxicity.
Azoles (such as fluconazole, ketoconazole, itraconazole)
inhibit the enzyme that synthesizes ergosterol