Easy Coagulation Cascade (1 of 2) - Simple & easy to remember

I'm a med student at Midwestern University's Chicago College of Osteopathic Medicine. I always hated trying to learn the coagulation pathways until I found a way that was simple enough for me to retain.

This video is intended to help you:
1) remember the factors and their place in the coagulation pathway
2) remember those which require vitamin K (for their synthesis)
3) remember those that require calcium (to be activated)

If this video was a little too simple, I continue adding details to this drawing in part 2.

Note: Feel free to correct any mistakes I've made in the comments, or better yet, post a better video yourself. Maybe one day everyone will understand this stuff. Also, I can't guarantee the details of what I'm presenting are accurate, although I've tried. Make sure to double check all medical knowledge against proper sources.

[Webermt]

I always come back to this one when I start to forget the details every year. Seriously thank you.
Oh and I remember you test Extrensic with PT and Intrinsic with PTT. (My mnemonic for that is you Play Tennis outside, and you Play Table Tennis Inside)

[jennifert]

I've seriously been watching cascade videos for the past hour or more without getting it, and this just did it for me in 6mins! BRILLIANT! ty for uploading

[JimiJegede]

Where has this been through out all my time in med school?? Thanks Andrew. Great job!

[mimigottfried]

I remember watching this video in my 2nd year for my Biochemistry exam and in my 3rd year for my Clinical Biochemistry exam.

Now I'm in my 5th year and I'm watching this video for my Hematology exam. This video is truly a timeless classic haha. Well done.

[bindubalayadash]

Hi Andrew, I want a autograph of you.You can't even imagine in which level you helped me.I am a Zoology student and there is a weekly seminar held in our college regularly.My topic was 'Blood and its Coagulation'.But I can't understand coagulation process really.You are true that no picture in our textbooks that makes any sense to me.I started getting worry but you appeared as a life saver.I understand this topic in only 6 mins 27 secs.This complicated topic now stored in my brain for my lifetime.You are simply superb and thousands times more than my teachers.I can't remember any of my teacher has able to explain me such a complicated topic in only 6 mins 27 secs.(In this case due to lack of communication I can't ask this topic to my zoology madam from whose I was guided but she is the

[yuliyalinhares]

Andrew, you rock. I am preparing for my Hematology Boards (6 years after med. school!), and your simple outline really helped me organize the cascade in my brain. Thank you! I wish you an increadible medical career.

[sweetyetunrefined]

THANK YOU!!!! You are a God-send. I'm giving my preliminary exam today, and this was so useful.

[NikkiPea]

This was AWESOME! I've made my own little charts but I really like how this one put everything together without all the clutter. Perfect for my hematology exam tomorrow =)

[adamheinemann]

Just started studying for step 1 and this has made so much more sense than anything my lecturers have given me. Thanks for sharing.

[TheVoidofNothing]

Holy Smokes man.... I know you posted this 5 years ago, but I hope you still read these comments! Great great way to memorize this and put the puzzle pieces together thank you for sharing!

[jiggamaaan]

Thanks Andrew... final exam tomorrow... this turned a whole lecture into 10 mins of youtube... appreciated man.

[skatesandkicks]

Hey Andrew, that was a fantastic little video. Probably the simplest and the best. Clarity is everything. I haven't watched part two yet, so I don't know if you've explained it yet, but you may want to add in that Thromboplastin is comprised of Tissue Factor and phospholipids. I know most text books out there, university lecture notes (non-in depth), and diagrams on the internet substitute thromboplastin with just tissue factor, and this may confuse some people. I look forward to more of your videos :) Thank you.

[pnarain]

This video has been super helpful in the first 2 years of medical school - and my classmates agree. :) Now I love the coagulation cascade. Thank you! 

[studentipap]

This is the Best COAG Review I've ever seen!! Helped SO Much Thank you!!! I was taught in class that Factor VII required Tissue Factor (Factor III) but that's a minor point. Thank you again!!

[farroos]

You are amazing mate. Amazing. I swear I've looking into figures and charts for days, this is the first time I actually understand the cascade AND memorize it. Thank you!

[kanyeasst]

I still comeback to this and been recommending this to all my friends. So easy thanks

[glistalyx]

I come back to this whenever I need to refresh my memory…learnt it years ago with you :)

[rhysy]

This was very helpful! I'm studying medicine at the moment. Exams are two weeks away and this is the first explanation I've seen which makes sense :) Cheers.

[alexwilkinson]

Thank you for posting this. I may have interpreted the video wrong, but just in case: my A&P book says factor 7, of the extrinsic pathway, is "proconvertin, " & "thromboplastin" is factor 9, of the intrinsic pathway. I'm usually oblivious to details like this, but it was amongst my practice questions for a final (to state whether thromboplastin was of the extrinsic, intrinsic, or common pathway, ) & I kept getting it wrong after reviewing this. .. :P ***Submitted with respect and gratitude***

[angelang]

This is great and makes it so much more easier to understand. One little thing to add, I've read a lot of different books and sites and factor 2a activates 11 as well. So just another arrow on your diagram and it's perfect !