Epigenetics

You know all about how DNA bases can code for an organism's traits, but did you know there's more influencing phenotype than just the bases? Explore epigenetics with the Amoeba Sisters by learning about a few types of epigenetic marks and some examples of them in action.

Contents:
00:00 Intro
2:14 Epigenetic Marks
4:13 Studies Involving Rodents & Epigenetics
5:51 Points about Inheritance and Factors Involving Inheritance
7:01 Why study Epigentics?
7:51 Epigentic Therapy
------------------------
REFERENCES:

Klug, William S, Michael R Cummings, Charlotte A Spencer, Michael Angelo Palladino, and Darrell Killian. Essentials of Genetics. Hoboken: Pearson, 2020.

Adams, J. (2008) Obesity, epigenetics, and gene regulation. Nature Education 1(1):128

Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. Epigenetic programming by maternal behavior. Nat Neurosci. 2004 Aug;7(8):847-54. doi: 10.1038/nn1276. Epub 2004 Jun 27. PMID: 15220929.

Robert A. Waterland, Randy L. Jirtle
Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation
Molecular and Cellular Biology Aug 2003, 23 (15) 5293-5300; DOI: 10.1128/MCB.23.15.5293-5300.2003

Dana C. Dolinoy, Dale Huang, Randy L. Jirtle
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development

Simmons, D. (2008) Epigenetic influence and disease. Nature Education 1(1):6

----------------------------
FURTHER READING SUGGESTIONS:

This website is phenomenal for learning about epigenetics, and it was recommended in Pinky’s graduate course.

More about histones?

We mention these are only some examples of epigenetic marks. What others exist? Check out this further reading which mentions Micro-RNAs.

What do we mean about epigenetic tags being “cleared?” Two great further readings:

Epigenetic therapy with diseases?

----------------------------
Our Resources:

Connect with us!

MUSIC:
Intro music designed & performed by Jeremiah Cheshire.
End music listed free to use/no attribution required from YouTube audio library.

TRANSLATIONS:
Turkish Subtitles by Kardelen Karaman

[papuleabdulrahman]

I just discovered this channel and wtf biology is actually interesting

[tiffanysotomi]

i just want to say that you guys have helped me so much in hs and you’re still helping me in university 🥰🥰

[hdgdjgsgfj]

I recently discovered this channel while browsing the topic of biomolecules and I have to say that it is quite impressive! Thank you so much! Subscribed immediately after watching that video.

[ushasharma]

Me when I saw the title - Epicgenetics? Why of course genetics are always epic
Me realising that title is 'Epigenetics' - Oh but genetics is still very epic

[warrenlehmkuhleii]

“It doesn’t work on a punnet square.”
High school biology has lied to me.

[sunsunnn_]

My teachers always play your videos, and they help me so much for midterms 😭😂 thank u!

[bshr]

I don't really need to watch this video right now, I just came here to like the video and thank these two amazing sisters for their efforts ❤️❤️❤️❤️

[snow]

During quarantine I watched all your videos because I was bored, and now they are the reason I am making it through 9th grade honors bio. Thank you!

[yashrana]

Amoeba sisters cleared my all concepts that were fading while studying in my school :) thnx u sister

[SkycryEmpathy]

These are seriously some of the cutest videos I’ve ever seen! And I love the educational value of them! Thank you amoeba sisters keep up the excellent work! 💖

[cartoondoggy]

Pinky! This is one of my favorite topics too. Have you read about the Dutch Hunger Winter? Or learned about how the fetus's size is affected by epigenetic markers from mom and dad? Fascinating stuff.

[shriyayadalam]

U guys have helped me so muchhhh for my exams making the content easier to study and fun to learn
Sincere thanks!🥰

[yousefzedan]

Finally my science teacher has seen the light.... She starting using Amoeba sisters today! Keep making awesome vids!

[lovekissy]

amoeba sisters really coming in clutch to save my grades lol #failingscience

[meranda]

This video is so interesting. Since middle school to undergrad I have never heard any teacher talk about this and I actually randomly stumbled across it while reviewing for a genetics exam so thanks! Biology is finally a not repetitive science to learn about

[robynwildwood]

Hi! I absolutely love you girls much and I don’t think I’ve ever found a learning method quite as good as this. You make really complicated things just so easy to understand its incredible. I wish you covered more topics!! Please consider branching out or partnering up with other topics. Thank you ❤️❤️

[kimssr]

Oh my god. This is the best educational video channel I have ever seen! It is so addictively cute to watch!

[zuzannagradek]

Others:Get excited about wild parties, travel and extreme sports.
Me:gets excited beacuse the amoeba sisters posted a new video.

[heyitzsamurai]

thank you!! often after i finish reading the chapter in my textbook i feel overwhelmed by the information. watching these videos helps sum up the big ideas and it really helps 😊

[cgmehta]

It's funny because I'm in 10th grade rn doing AP Biology. My teacher showed us about epigenetics and it was SUPER cool!!! I agree with your interest in this topic!!