4 neurodegeneratives cases treated with Blood Derived Stem Cells

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FIRST CASE
This is a 27 year old horse, very old, with a neurodegenerative pathology: PPID Pituitary Pars Intermedia Dysfunction with cerebral lesions identical to Parkinson’s disease.
It is a pathology that causes excessive hair growth, general bad state and in 6% of cases can cause blindness. As any neurodegenerative disease, age is the primary risk factor and progression of clinical signs occurs slowly.
This subject already had an old cataract in the left eye, but had now lost sight in the other eye.
In this case a single BDSCs I.V. injection was given and after 40 days the horse regained his sight.
100 days later the horse had lost 10 years and moved better than younger competing horses.

SECOND CASE
Hirsutism is the classic and most consistent sign in PPID, other hair coat abnormalities are incomplete shedding and lightening of coat color in aged horses. Hirsutism was found to have a positive predictive value of 90% for PPID.
Here the symptom is very evident
1-Time zero. Pituitary Pars Intermedia Dysfunction is similar to Parkinson's disease.
2-time zero facial hair makes her look like a bison
3-time zero nasal discharge and eye inflammation
4- 5 days after first injection some facial hair has fallen out
5- 20 days after first injection her coat has become curly like a sheep's
6- 20 days after first injection even less facial hair
7- time zero note long hair on her bottom
8- 20 days later curlier coat and hair loss begins near the tail
9- 40 days later a 50% hair loss
10- 40 days later facial hair almost normal
11-40 days later hair loss on the bottom
12- 70 days later almost normal facial hair
13- 70 days later a 90% hair loss
Such long hair is the symptom of a neurodegenerative disease and the BDCSs were effective

THIRD CASE
The degenerative pathologies of the cardiac muscle (myocardium) create a consequent functional deficit and the heart doesn’t work properly anymore.

Given the incapacity of the myocardial tissue to regenerate the degenerated myofibrils, treatment is currently aimed at neutralizing the physiological compensation mechanisms of cardiac insufficiency.
The clinical symptoms of the disease are weight loss, intolerance to exercise, cough, objective signs of right/left decompensation, arrhythmias, murmurs leading to the extreme consequences of usually right/left decompensation

1-This ultrasound shows the outcome of a dilated cardiomyopathy in a 5 year old dog. It is phase 4, where the myocardium hardly contracts anymore and in a short time will be fatal. The dog received the only therapy available that is compensatory and cannot restore myocardium contractility.
The dog was very tired.
2-The yellow line shows the bad myocardium contraction. At this point BDSCs were inoculated I.V. and under the skin around the heart. A non invasive treatment lasting a few minutes.
3- In a month the pathology went from phase 4 to phase 2. This is miraculous because no drug gives this result. We repeated the treatment and the dog was checked 60 days later.
4- Look at the yellow line!
After 3 months the dog is now phase 0 and has completely recovered his old vitality.

5 month later the dog’s medicine has been reduced and the diuretics stopped, he has returned to his normal life. Dilated cardiomyopathy in human medicine often represents the terminal stage of ischemic disease and the first thoughts of Giorgio Cagni, cardiologist that works with me, were the application of this therapy on heart attack patients. Until BDSCs for dilated cardiomyopathy will be used, the only treatment is the very expensive and invasive heart transplant.
Another topic regards arrhythmia: this Doberman had many extrasystolic episodes (more than 20 in a minute),but after BDSCs injection, we saw not the reduction of these episodes but their complete disappearance and for arrhythmia this is a new therapeutic horizon.

FORTH CASE
This is a small 4 year old bitch who had an emergency operation, by an excellent surgeon, for a slipped disc when her hindquarters were completely paralysed. After surgery she reacquired deep feeling then was able to stand on four legs for a few seconds and take some uncoordinated steps. For 3 months there was a slight improvement but even though she had regular physiotherapy the dog regressed. The owner decided to try stem cells and I injected BDSCs locally and I.V. You can see her on the first day , one month and 5 months after the first inoculation, the result is miraculous.